Molecular Partners to present at the Morgan Stanley Global Healthcare Conference in New York

Molecular Partners to present at the Morgan Stanley Global Healthcare Conference in New York

Zurich-Schlieren, September 07, 2017. Molecular Partners AG (SIX: MOLN), a clinical-stage biopharmaceutical company that is developing a new class of drugs, known as DARPin® therapies, today announced that Dr. Patrick Amstutz, CEO and Andreas Emmenegger, CFO of Molecular Partners will participate in a fireside chat at the Morgan Stanley Global Healthcare Conference on
Tuesday, September 12, 2017 at 4:40 PM Eastern Time (10:40 PM CET).

The presentation will be available for viewing via live webcast and can be accessed on the day through this link. A replay of the webcast will be made available on the company’s website www.molecularpartners.com under the Investors section. The replay will be available for 180 days following the presentation.

 

About Molecular Partners AG

Molecular Partners AG is a clinical-stage biopharmaceutical company that is developing a new class of therapies known as DARPin® therapies. With a management team that includes many of the founding scientists, the company continues to attract talented individuals who share the
passion to develop breakthrough medicines for serious diseases. Molecular Partners has compounds in various stages of clinical and preclinical development and several more in the research stage, with a current focus on ophthalmology and oncology. The company establishes research and development partnerships with leading pharmaceutical companies and is backed by established biotech investors.
For more information regarding Molecular Partners AG, go to: www.molecularpartners.com.

 

For further details please contact:

Dr. Patrick Amstutz, CEO
patrick.amstutz@molecularpartners.com
Tel: +41 (0) 44 755 77 00

Andreas.Emmenegger, CFO
andreas.emmenegger@molecularpartners.com
Tel: +41 (0) 44 755 77 00

Rolf Schläpfer
Hirzel.Neef.Schmid.Counselors
rolf.schlaepfer@konsulenten.ch
Tel: +41 (0) 43 344 42 42

Susan A. Noonan
S.A. Noonan Communications, LLC
susan@sanoonan.com
Tel: +1 212 966 3650

Molecular Partners reports key financials and corporate highlights for H1 2017: Pipeline development on track with several key milestones ahead

Research & Development highlights:

  • Abicipar: Allergan completed patient recruitment in both wet AMD phase 3 studies four months ahead of schedule
  • MP0250: First patients dosed in phase 2 Multiple Myeloma study; Trial in progress poster to be presented at ESMO Madrid in September 2017
  • MP0250: IND submitted to FDA for MP0250 in EGFR-mutated Non-Small Cell Lung Cancer (EGFR mut NSCLC) in August 2017
  • MP0250: Phase 1 recruitment completed with 45 patients
  • MP0274: Full country approvals received in Switzerland and UK for phase 1 trial of multi-specific DARPin® candidate for treatment of HER2-positive solid tumors; first patient expected for September 2017
  • Immuno-oncology: Further data on proprietary immuno-oncology programs presented at European Association for Cancer Research in Florence indicating tumor-restricted mode of action

Team highlights:

  • Patrick Amstutz appointed Chief Executive Officer in May 2017
  • Gwen Fyfe, MD, elected to the Board of Directors
  • 104 full-time employees, up 2% year-over-year as well as compared to year-end 2016, with a build-out of the clinical team

Financial highlights:

  • Financial position in H1 2017 continued to develop in line with expectations and guidance
  • Ongoing strong financial position with CHF 156.9 million in cash and short-term time deposits on hand as of June 30, 2017
  • Net cash used in operating activities of CHF 20.5 million in H1 2017, reflecting scale-up of R&D, pipeline growth and progress of proprietary clinical programs
  • Operating loss of CHF 16.7 million and net loss of CHF 19.4 million in the first half 2017
  • Venture capital holdings reduced to 28% from 42%; Shareholder base diversified as private investors acquired shares from venture capitalists in secondary block trades

Zurich-Schlieren, August 30, 2017. Molecular Partners AG (SIX: MOLN), a clinical-stage biopharmaceutical company that is developing a new class of drugs, known as DARPin® therapies, today announced its unaudited financial results for the first half year 2017. During the semester, the company achieved two key clinical milestones: the completion of full enrollment in its two phase 3 clinical trials of abicipar in wet AMD, and the dosing of the first patient in the phase 2 trial of MP0250 in multiple myeloma. In addition, the company diversified its shareholder base through the acquisition of a substantial portion of the venture capital investors’ shareholdings by new private investors.

“We are very pleased with the progress we made advancing our broad pipeline of DARPin® drug candidates during the first semester of 2017,” said Dr. Patrick Amstutz, Chief Executive Officer of Molecular Partners. “In ophthalmology, Allergan achieved full enrollment in the two phase 3 clinical trials of abicipar, the most advanced DARPin® molecule in our pipeline, which we are developing in collaboration with Allergan for the treatment of wet-DMD, four months ahead of schedule. For our lead oncology asset MP0250, we have enrolled the first patients in our multiple myeloma phase 2 clinical trial and we announced NSCLC as the second indication for this promising oncology compound. Finally, we presented compelling additional mode of action data on MP0274, as well as on our growing immuno-oncology franchise at the AACR in April 2017. We are well-positioned to sustain this momentum through the back half of the year.”

Patient recruitment in phase 3 trials of abicipar in wet AMD completed ahead of schedule

Patient enrollment in the two phase 3 clinical trials of abicipar for patients with wet age-related macular degeneration (wet AMD) was completed four months ahead of schedule. The company anticipates one-year efficacy data in H2 2018. A further milestone for the company will be the start of a phase 3 trial of abicipar in diabetic macular edema (DME).

First patients dosed in phase 2 study of MP0250

The phase 2 study of MP0250, Molecular Partners’ lead oncology asset, is evaluating this agent in combination with bortezomib (Velcade®) and dexamethasone in patients with multiple myeloma who have failed standard therapies. For this study, the first patients have been dosed. The study will occur at centers in Germany, Poland and Italy and will measure the efficacy and safety of MP0250. The company anticipates initial safety data in 2017 and will present a poster at the “Trial in Progress” session at the annual meeting of the European Society of Molecular Oncology (ESMO) in Madrid in September 2017. The company expects to receive efficacy data in 2018.

Non-Small Cell Lung Cancer (NSCLC) announced as second indication for phase 2 trial of MP0250

In addition to the ongoing studies in multiple myeloma, the company announced that MP0250 will also be evaluated in solid tumors. In August 2017, Molecular Partners submitted to the FDA an Investigational New Drug Application (IND) for a phase 1b/2 study of MP0250 in combination with osimertinib (Tagrisso®) in patients with EGFR-mutated Non-Small Cell Lung Cancer (NSCLC) pretreated with osimertinib. Osimertinib, a third-generation TKI targeting EGFR (Epidermal Growth Factor Receptor), has recently become the standard of care for NSCLC patients who harbor a T790M mutation. Despite the availability of osimertinib, however, patients eventually relapse and treatments become ineffective, creating a significant unmet medical need. Targeting HGF and VEGF simultaneously, MP0250 administered in combination with osimertinib offers the possibility to target two of the described escape pathways.

“We are pleased to have reached this important milestone to dose the first patients in our multiple myeloma phase 2 study,” commented Dr. Andreas Harstrick, Chief Medical Officer at Molecular Partners. “Looking forward, we are eager to test our hypothesis that MP0250, as part of a combination therapy, can address resistance pathways in both hematological and solid tumors, and, to that end, we submitted an IND for our first solid tumor indication in August 2017.”

Compelling MP0274 data presented at AACR Annual Meeting

Molecular Partners received regulatory approvals in Switzerland and UK for its phase 1 trial of MP0274, its multi-specific DARPin® candidate for the treatment of HER2-positive solid tumors. The study initiation is expected in September 2017. MP0274 is a proprietary DARPin® drug candidate for the treatment of HER2-positive cancer with a completely new mode of action compared to current standard of care antibodies. In an oral presentation at the AACR Annual Meeting on April 4, 2017, the company was able to highlight the unique and distinct inhibition of the HER2 signaling cascade, different from trastuzumab, pertuzumab and the combination of both. As the data show, MP0274 induces a profound inhibition of specific downstream signaling pathways, providing mechanistic support to the finding that MP0274 directly kills HER2-addicted tumor cells through the induction of apoptosis.

Progress on the immuno-oncology DARPin® pipeline

Molecular Partners is advancing its immuno-oncology pipeline. Posters were presented at AACR and the EACR conferences, demonstrating the use of multi-specific DARPin® molecules in immuno-oncology, including the simultaneous blocking of PD-1 and VEGF and tumor restricted T-cell activation.

Significant reduction in VC holdings and diversification of shareholder base

On April 6, 2017, Molecular Partners disclosed a substantial reduction in the number of the company’s shares held by venture capital firms. Index Ventures Funds fell below 10% to 8.18%, Essex Woodlands Health Ventures Funds below 10% to 7.82%, and Johnson & Johnson Innovation, below 5% to 4.25%. As a result, venture capital investors now own 28% of the company’s share capital, versus 42% at the end of 2016. Several private investors acquired these shares from the venture capitalist investors in secondary block trades.

Financial highlights: Ongoing strong cash position, increased development expenses

In the first half-year 2017, Molecular Partners recognized total revenues of CHF 6.0 million (H1 2016: CHF 13.5 million) and incurred operating expenses of CHF 22.7 million (H1 2016: CHF 22.0 million) in line with expectations. This led to an operating loss of CHF 16.7 million for the first half-year (H1 2016: operating loss of CHF 8.5 million). The company recognized net financing expenses of CHF 2.7 million (H1 2016: CHF 1.2 million), mainly driven by negative FX effects on the USD and EUR cash positions. This resulted in a net loss of CHF 19.4 million for the first half-year 2017 (H1 2016: CHF 9.7 million).

The net cash used from operating activities during the first semester 2017 was CHF 20.5 million (H1 2016: net cash used of CHF 17.5 million). Including time deposits, the cash and cash equivalents position decreased by CHF 23.3 million to CHF 156.9 million as of June 30, 2017 (December 31, 2016: CHF 180.2 million). The total shareholders’ equity decreased to CHF 118.3 million as of June 30, 2017 (December 31, 2016: CHF 135.8 million).

As of June 30, 2017, the company employed 104 FTEs, up 2% year-over-year as well as compared to year-end 2016. About 90% of the 104 FTEs are employed in R&D related functions.

Key figures as of June 30, 2017

Key Financials (unaudited)
(CHF million, except per share, FTE data)

H1 2017

H1 2016

change

Total revenues

6.0

13.5

-7.5

R&D expenses

-18.9

-18.1

-0.8

G&A expenses

-3.8

-3.9

0.1

Operating result

-16.7

-8.5

-8.2

Net result

-19.4

-9.7

-9.7

Basic net result per share (in CHF)

-0.93

-0.48

-0.45

Net cash from (used in) operating activities

-20.5

-17.5

-3.0

Cash balance (incl. time deposits) as of June 30

156.9

196.3

-39.4

Total shareholders’ equity as of June 30

118.3

141.4

-23.1

Number of total FTE as of June 30

104.4

102.4

2.0

– thereof in R&D

92.8

93.4

-0.6

– thereof in G&A

11.6

9.0

2.6

“The substantial shareholder rotation that occurred in April was an important event for the company,” said Andreas Emmenegger, Chief Financial Officer of Molecular Partners. “During the first half-year 2017, Molecular Partners’ financial position continued to develop in line with our expectations. Our strong cash position provides us with the financial flexibility and a forecasted cash runway through the end of 2019 – well beyond key value inflection points.”

Patrick Amstutz appointed CEO

On May 12, the Board of Directors unanimously appointed Patrick Amstutz, Ph.D. and co-founder of the company, as Chief Executive Officer and nominated him to become a member of the Board. Patrick Amstutz had been Molecular Partners’ interim acting CEO since November 2016.

Gwen Fyfe appointed to the Board of Directors

At the annual general meeting of May 12, 2017, Gwen Fyfe, M.D., was elected as a new member of the Board of Directors. With her extensive experience in developing antibodies for Genentech, including Rituxan®, Herceptin®, Avastin® and Tarceva®, Gwen strengthens the footprint of Molecular Partners in oncology.

Business outlook and priorities

For the company’s proprietary oncology pipeline, initial safety data from the phase 2 trial of MP0250 in patients with multiple myeloma (MM) are expected in 2017 and efficacy data is expected for 2018. With regard to the phase 1b/2 trial of MP0250 for NSLC, the first solid tumor indication to be treated with this DARPin® drug candidate, initial safety data are expected in 2018. For MP0274, a proprietary, single-pathway DARPin® drug candidate for the treatment of HER2-positive cancer, the company expects to initiate the corresponding phase 1 trial in September 2017.

The company will continue to advance its immuno-oncology pipeline and will present further research data in the second half of 2017. In this attractive field, Molecular Partners has shown the potential utility of targeting immune checkpoint modulators (ICMs) via combination therapy (e.g., simultaneous inhibition of PD-1 and VEGF) or activating agonists in a tumor-restricted way.

In ophthalmology, Molecular Partners will continue to support its strategic partner Allergan in advancing abicipar through phase 3 trials in patients with wet AMD and in initiating the phase 3 trials of abicipar in patients with DME, the next retinal indication.

R&D day in New York on November 9, 2017

Molecular Partners will host an R&D Update in New York City on Thursday, November 9, 2017, from 11:45 – 2:30 EST. The luncheon meeting will feature presentations by key opinion leaders (KOLs) who will discuss current oncology treatments in fields where the company has clinical programs and unmet medical needs for these patients. Molecular Partners’ management team will also provide an overview of the company’s DARPin® platform technology and its pipeline of oncology and ophthalmology programs. For details and to reserve a seat, please contact: Susan Noonan at susan@sanoonan.com.

Financial outlook 2017

As the first half 2017 developed fully in line with management expectations, Molecular Partners reiterates all elements of the financial outlook 2017 as provided with the company’s 2016 full-year results on February 9, 2017 as well as in the company’s quarterly management statement on May 4, 2017.

For the full year 2017, at constant exchange rates, the company expects to incur total expenses of approximately CHF 50-60 million, of which approximately CHF 6 million will be non-cash effective costs for share-based payments, IFRS pension accounting and depreciations. However, this guidance is subject to the progress of the pipeline, mainly driven by manufacturing costs, the speed of enrollment of patients in clinical trials and data from research and development projects.

Investor documentation of H1 2017 results

The H1 2017 results presentation, the H1 2017 press release as well as the unaudited Financial Statements for H1 2017 and the company’s H1 2017 Report and additional information are available on the investors section of the company’ website.

Conference call and audio webcast

Molecular Partners will conduct a conference call and audio webcast of the company’s H1 2017 results on August 30, 2017, 2:00pm CET (1:00pm GMT, 8:00am EST).
In order to register for the H1 2017 conference call, please dial the following numbers approximately 10 minutes before the start of the presentation:

Switzerland / Europe +41 (0) 58 310 5000
UK +44 (0) 203 059 5862
USA +1 (1) 631 570 5613

Participants will have the opportunity to ask questions after the presentation.

The H1 17 audio webcast will be accessible, both live and as a replay, on the Investors section of the company’s website www.molecularpartners.com, along with the accompanying presentation slides.

Financial Calendar

October 26, 2017 Q3 2017 Management Statement
November 9, 2017 R&D Day in New York
February 8, 2018 Publication of Full-year Results 2017 (unaudited)
March 16, 2018 Expected Publication of Annual Report 2017
April 18, 2018 Annual General Meeting

http://investors.molecularpartners.com/financial-calendar-and-events/

About the DARPin® Difference

DARPin® therapeutics are a new class of protein therapeutics opening an extra dimension of multi-specificity and multi-functionality. DARPin® candidates are potent, specific, safe and very versatile. They can engage in more than 5 targets at once, offering potential benefits over those offered by conventional monoclonal antibodies or other currently available protein therapeutics.
The DARPin® technology is a fast and cost-effective drug discovery engine, producing drug
candidates with ideal properties for development and very high production yields.

With their good safety profile, low immunogenicity and long half-life in the bloodstream and the eye, DARPin® therapies have the potential to advance modern medicine and significantly improve the treatment of serious diseases, including cancer and sight-threatening disorders. Molecular
Partners is partnering with Allergan to advance clinical programs in ophthalmology, and is advancing a proprietary pipeline of DARPin® drug candidates in oncology. The most advanced global product candidate is abicipar, a molecule currently in phase 3, in partnership with Allergan. Several DARPin® molecules for various ophthalmic indications are also in development. The most
advanced systemic DARPin® molecule, MP0250, is in phase 1 clinical development for the treatment of solid tumors and has entered into phase 2 development for hematological tumors. In addition, Molecular Partners intends to further evaluate MP0250 for solid tumors in a phase 1b/2 trial for EGFR-mutated NSCLC. MP0274, the second-most advanced DARPin® drug
candidate in oncology, has broad anti-HER activity; it inhibits HER1, HER2 and HER3-mediated
downstream signaling via Her2, leading to induction of apoptosis. MP0274 is currently moving into phase 1. Molecular Partners is also advancing a growing preclinical pipeline that features several immuno-oncological development programs. DARPin® is a registered trademark owned by
Molecular Partners AG.

About Molecular Partners AG

Molecular Partners AG is a clinical-stage biopharmaceutical company that is developing a new class of therapies known as DARPin® therapies. With a management team that includes many of the founding scientists, the company continues to attract talented individuals who share the
passion to develop breakthrough medicines for serious diseases. Molecular Partners has compounds in various stages of clinical and preclinical development and several more in the research stage, with a current focus on ophthalmology and oncology. The company establishes research and development partnerships with leading pharmaceutical companies and is backed by established biotech investors.
For more information regarding Molecular Partners AG, go to: www.molecularpartners.com.

For further details please contact:

Dr. Patrick Amstutz, CEO
patrick.amstutz@molecularpartners.com
Tel: +41 (0) 44 755 77 00

Andreas.Emmenegger, CFO
andreas.emmenegger@molecularpartners.com
Tel: +41 (0) 44 755 77 00

Rolf Schläpfer
Hirzel.Neef.Schmid.Counselors
rolf.schlaepfer@konsulenten.ch
Tel: +41 (0) 43 344 42 42

Susan A. Noonan
S.A. Noonan Communications, LLC
susan@sanoonan.com
Tel: +1 212 966 3650

Disclaimer

This communication does not constitute an offer or invitation to subscribe for or purchase any securities of Molecular Partners AG. This publication may contain certain forward-looking statements and assessments or intentions concerning the company and its business. Such statements involve certain risks, uncertainties and other factors which could cause the actual results, financial condition, performance or achievements of the company to be materially different from those expressed or implied by such statements. Readers should therefore not place reliance on these statements, particularly not in connection with any contract or investment decision. The company disclaims any obligation to update these forward-looking statements, assessments or intentions.

Molecular Partners provides additional details on clinical studies of proprietary lead oncology asset MP0250

  • First patient dosed in phase 2 Multiple Myeloma study
  • IND submission to FDA in H2 2017 planned for MP0250 in EGFR-mutated Non-Small Cell Lung Cancer (EGFR mut NSCLC)

Zurich-Schlieren, May 30, 2017. Molecular Partners AG (SIX: MOLN), a clinical-stage biopharmaceutical company developing a new class of drugs known as DARPin® therapies, today announced that the first patient was dosed in the phase 2 multiple myeloma study of its lead oncology asset MP0250. In the first phase 2 study, the efficacy and safety of MP0250 will be examined in combination with bortezomib (Velcade®) and dexamethasone in patients with multiple myeloma who have failed standard therapies. The study will be performed in three different countries: Germany, Poland and Italy. Initial safety data are expected in 2017 and efficacy data in 2018.

In addition, the company announced that MP0250 will also be further evaluated in solid tumors. Molecular Partners intends submit to the FDA in H2 2017 an Investigational New Drug Application (IND) for a phase 1b/2 trial of MP0250 in combination with osimertinib (Tagrisso®) in EGFR-mutated T790M-positive Non-Small Cell Lung Cancer (NSCLC) patients. Osimertinib, a third-generation TKI targeting EGFR (Epidermal Growth Factor Receptor), has recently become the standard treatment for those NSCLC patients which harbor a T790M mutation. Despite this novel treatment, patients eventually relapse and treatments become ineffective. MP0250 offers the possibility to target two of the described escape pathways – HGF and VEGF. The combination of MP0250 with osimertinib is expected to continuously block the EGFR-mutated pathway and simultaneously inhibit two additional non-EGFR related pathways of resistance.

“We are pleased and proud to have reached this important milestone to dose the first patient in our multiple myeloma phase 2 study. This is the first step to test our hypothesis that MP0250 can address resistance pathways in various hematological and solid tumors. The submission of an IND for the first solid tumor indication will be another important milestone in the development program of our lead oncology asset MP0250 later this year,” commented Dr. Andreas Harstrick, Chief Medical Officer at Molecular Partners.

Financial Calendar

August 30, 2017 Publication of 2017 Half-year Results
October 26, 2017 Q3 2017 Management Statement

http://investors.molecularpartners.com/financial-calendar-and-events/

About the DARPin® Difference

DARPin® therapeutics are a new class of protein therapeutics opening an extra dimension of multi-specificity and multi-functionality. DARPin® candidates are potent, specific, safe and very versatile. They can engage in more than 5 targets at once, offering potential benefits over those offered by conventional monoclonal antibodies or other currently available protein therapeutics.
The DARPin® technology is a fast and cost-effective drug discovery engine, producing drug candidates with ideal properties for development and very high production yields.

With their good safety profile, low immunogenicity and long half-life in the bloodstream and the eye, DARPin® therapies have the potential to advance modern medicine and significantly improve the treatment of serious diseases, including cancer and sight-threatening disorders. Molecular Partners is partnering with Allergan to advance clinical programs in ophthalmology, and is advancing a proprietary pipeline of DARPin® drug candidates in oncology. The most advanced global product candidate is abicipar, a molecule currently in Phase 3, in partnership with Allergan. Several DARPin® molecules for various ophthalmic indications are also in development. The most advanced systemic DARPin® molecule, MP0250, is in Phase 1 clinical development for the treatment of solid tumors and has entered into Phase 2 development for hematological tumors. In addition, Molecular Partners intends to further evaluate MP0250 for solid tumors in a phase 1b/2 trial for EGFR-mutated T790M-positive NSCLC. MP0274, the second-most advanced DARPin® drug candidate in oncology, has broad anti-HER activity; it inhibits HER1, HER2 and HER3-mediated downstream signaling via Her2, leading to induction of apoptosis. MP0274 is currently moving into Phase 1. Molecular Partners is also advancing a growing preclinical pipeline that features several immuno-oncological development programs. DARPin® is a registered trademark owned by Molecular Partners AG.

About Molecular Partners AG

MMolecular Partners AG is a clinical-stage biopharmaceutical company that is developing a new class of therapies known as DARPin® therapies. With a management team that includes many of the founding scientists, the company continues to attract talented individuals who share the passion to develop breakthrough medicines for serious diseases. Molecular Partners has compounds in various stages of clinical and preclinical development and several more in the research stage, with a current focus on ophthalmology and oncology. The company establishes research and development partnerships with leading pharmaceutical companies and is backed by established biotech investors.
For more information regarding Molecular Partners AG, go to: www.molecularpartners.com.

For further details please contact:

Dr. Patrick Amstutz, CEO
patrick.amstutz@molecularpartners.com
Tel: +41 (0) 44 755 77 00

Andreas.Emmenegger, CFO
andreas.emmenegger@molecularpartners.com
Tel: +41 (0) 44 755 77 00

Rolf Schläpfer
Hirzel.Neef.Schmid.Counselors
rolf.schlaepfer@konsulenten.ch
Tel: +41 (0) 43 344 42 42

Susan A. Noonan
S.A. Noonan Communications, LLC
susan@sanoonan.com
Tel: +1 212 966 3650

 

Disclaimer

This communication does not constitute an offer or invitation to subscribe for or purchase any securities of Molecular Partners AG. This publication may contain certain forward-looking statements and assessments or intentions concerning the company and its business. Such statements involve certain risks, uncertainties and other factors which could cause the actual results, financial condition, performance or achievements of the company to be materially different from those expressed or implied by such statements. Readers should therefore not place reliance on these statements, particularly not in connection with any contract or investment decision. The company disclaims any obligation to update these forward-looking statements, assessments or intentions.

Patrick Amstutz Appointed as Chief Executive Officer

Zurich-Schlieren, May 12, 2017. Molecular Partners AG (SIX: MOLN), a clinical-stage biopharmaceutical company developing a new class of drugs known as DARPin® therapies, today announced that the Board of Directors unanimously decided to appoint Patrick Amstutz, Ph.D., co-founder of the company, as Chief Executive Officer and to nominate him to become a member of the Board of Directors.

When Christian Zahnd resigned as CEO of Molecular Partners in November 2016, the Board of Directors appointed Patrick Amstutz as acting CEO, and engaged in a process to find the best suitable internal or external candidate. The Board of Directors is pleased to have concluded that Patrick Amstutz is best qualified to become the next CEO of the company.

“As a co-founder of Molecular Partners, Patrick has been a key member of the team building Molecular Partners. He has successfully demonstrated his leadership capabilities in business development and as a Chief Operating Officer for many years. Since he took over as acting CEO, he has led the company with full support of his team. The Board of Directors is convinced that Patrick will lead our company into a successful future,” commented Joern Aldag, Chairman of the Board of Directors.

Financial Calendar

August 30, 2017 Publication of 2017 Half-year Results
October 26, 2017 Q3 2017 Management Statement

http://investors.molecularpartners.com/financial-calendar-and-events/

 

About the DARPin® Difference

DARPin® therapeutics are a new class of protein therapeutics opening an extra dimension of multi-specificity and multi-functionality. DARPin® candidates are potent, specific, safe and very versatile. They can engage in more than 5 targets at once, offering potential benefits over those offered by conventional monoclonal antibodies or other currently available protein therapeutics. The DARPin® technology is a fast and cost-effective drug discovery engine, producing drug candidates with ideal properties for development and very high production yields.

With their good safety profile, low immunogenicity and long half-life in the bloodstream and the eye, DARPin® therapies have the potential to advance modern medicine and significantly improve the treatment of serious diseases, including cancer and sight-threatening disorders. Molecular Partners is partnering with Allergan to advance clinical programs in ophthalmology, and is advancing a proprietary pipeline of DARPin® drug candidates in oncology. The most advanced global product candidate is abicipar, a molecule currently in Phase 3, in partnership with Allergan. Several DARPin® molecules for various ophthalmic indications are also in development. The most advanced systemic DARPin® molecule, MP0250, is in Phase 1 clinical development for the treatment of solid tumors and moves into Phase 2 for hematological and later for solid tumors. MP0274, the second-most advanced DARPin® drug candidate in oncology, has broad anti-HER activity; it inhibits HER1, HER2 and HER3-mediated downstream signaling via Her2, leading to induction of apoptosis. MP0274 is currently moving in Phase 1. Molecular Partners is also advancing a growing preclinical pipeline that features several immuno-oncological development programs. DARPin® is a registered trademark owned by Molecular Partners AG.

 

About Molecular Partners AG

Molecular Partners AG is a clinical-stage biopharmaceutical company that is developing a new class of therapies known as DARPin® therapies. With a management team that includes many of the founding scientists, the company continues to attract talented individuals who share the passion to develop breakthrough medicines for serious diseases. Molecular Partners has compounds in various stages of clinical and preclinical development and several more in the research stage, with a current focus on ophthalmology and oncology. The company establishes research and development partnerships with leading pharmaceutical companies and is backed by established biotech investors.

For more information regarding Molecular Partners AG, go to: www.molecularpartners.com.

 

For further details please contact:

Dr. Patrick Amstutz, CEO
patrick.amstutz@molecularpartners.com
Tel: +41 (0) 44 755 77 00

Andreas.Emmenegger, CFO
andreas.emmenegger@molecularpartners.com
Tel: +41 (0) 44 755 77 00

Rolf Schläpfer
Hirzel.Neef.Schmid.Counselors
rolf.schlaepfer@konsulenten.ch
Tel: +41 (0) 43 344 42 42

Susan A. Noonan
S.A. Noonan Communications, LLC
susan@sanoonan.com
Tel: +1 212 966 3650

 

Disclaimer

This communication does not constitute an offer or invitation to subscribe for or purchase any securities of Molecular Partners AG. This publication may contain certain forward-looking statements and assessments or intentions concerning the company and its business. Such statements involve certain risks, uncertainties and other factors which could cause the actual results, financial condition, performance or achievements of the company to be materially different from those expressed or implied by such statements. Readers should therefore not place reliance on these statements, particularly not in connection with any contract or investment decision. The company disclaims any obligation to update these forward-looking statements, assessments or intentions.

Shareholders of Molecular Partners AG approved all Board proposals at the Annual General Meeting – Gwen Fyfe elected new Board member

Zurich-Schlieren, May 11, 2017. At today’s Annual General Meeting of Molecular Partners AG (SIX:MOLN), the shareholders of the company approved all motions proposed by the Board of Directors with a large majority and elected Gwen Fyfe as new member of the Board of Directors.

At today’s Annual General Assembly of Molecular Partners AG, Gwen Fyfe was elected as new member of the Board of Directors. Gwen has more than 20 years of drug development experience in oncology. She held various positions at Genentech from 1997-2009, including vice president, oncology development, playing an important role in the development of Genentech’s approved oncology agents.

Jörn Aldag, chairman of Molecular Partners commented: “We are very pleased to welcome Gwen as a new member of our Board. With her large experience in clinical oncology development, Gwen is the ideal person to support the advancement of our product candidates in oncology.”

Jörn Aldag, Goran Ando, Jeffrey H. Buchalter, Steven H. Holtzman, William A. Lee, Andreas Plückthun and Petri Vainio were all re-elected as members of the Board of Directors and Jörn Aldag was re-elected as Chairman of the Board of Directors. The proposed three members of the Compensation Committee – Jörn Aldag, William A. Lee and Petri Vainio – were also re-elected.

Further, the shareholders of Molecular Partners AG approved the annual report and the annual financial statements for the financial year 2016, the appropriation of the 2016 results, as well as the compensation report (in a consultative vote). The Board of Directors and the Management Board were granted discharge for the financial year 2016.

The shareholders of Molecular Partners AG also approved all proposals regarding compensation, including the proposed respective compensation amounts for the Board of Directors and the Management Board.

No guidance can be provided with regard to net cash flow projections. Timelines and potential milestone payments for existing and potentially new partnerships are not disclosed.

Financial Calendar

August 30, 2017 Publication of 2017 Half-year Results
October 26, 2017 Q3 2017 Management Statement

http://investors.molecularpartners.com/financial-calendar-and-events/

 

About the DARPin® Difference

DARPin® therapeutics are a new class of protein therapeutics opening an extra dimension of multi-specificity and multi-functionality. DARPin® candidates are potent, specific, safe and very versatile. They can engaging in more than 5 targets at once, offering potential benefits over those offered by conventional monoclonal antibodies or other currently available protein therapeutics.
The DARPin® technology is a fast and cost-effective drug discovery engine, producing drug candidates with ideal properties for development and very high production yields.

With their good safety profile, low immunogenicity and long half-life in the bloodstream and the eye, DARPin® therapies have the potential to advance modern medicine and significantly improve the treatment of serious diseases, including cancer and sight-threatening disorders. Molecular Partners is partnering with Allergan to advance clinical programs in ophthalmology, and is advancing a proprietary pipeline of DARPin® drug candidates in oncology. The most advanced global product candidate is abicipar, a molecule currently in Phase 3, in partnership with Allergan. Several DARPin® molecules for various ophthalmic indications are also in development. The most advanced systemic DARPin® molecule, MP0250, is in Phase 1 clinical development for the treatment of solid tumors and moves into Phase 2 for hematological and later for solid tumors. MP0274, the second-most advanced DARPin® drug candidate in oncology, has broad anti-HER activity; it inhibits HER1, HER2 and HER3-mediated downstream signaling via Her2, leading to induction of apoptosis. MP0274 is currently moving in Phase 1. Molecular Partners is also advancing a growing preclinical pipeline that features several immuno-oncological development programs. DARPin® is a registered trademark owned by Molecular Partners AG.

 

About Molecular Partners AG

Molecular Partners AG is a clinical-stage biopharmaceutical company that is developing a new class of therapies known as DARPin® therapies. With a management team that includes many of the founding scientists, the company continues to attract talented individuals who share the passion to develop breakthrough medicines for serious diseases. Molecular Partners has compounds in various stages of clinical and preclinical development and several more in the research stage, with a current focus on ophthalmology and oncology. The company establishes research and development partnerships with leading pharmaceutical companies and is backed by established biotech investors.

For more information regarding Molecular Partners AG, go to: www.molecularpartners.com.

 

For further details please contact:

Dr. Patrick Amstutz, acting CEO
patrick.amstutz@molecularpartners.com
Tel: +41 (0) 44 755 77 00

Andreas.Emmenegger, CFO
andreas.emmenegger@molecularpartners.com
Tel: +41 (0) 44 755 77 00

Rolf Schläpfer
Hirzel.Neef.Schmid.Counselors
rolf.schlaepfer@konsulenten.ch
Tel: +41 (0) 43 344 42 42

Susan A. Noonan
S.A. Noonan Communications, LLC
susan@sanoonan.com
Tel: +1 212 966 3650

 

Disclaimer

This communication does not constitute an offer or invitation to subscribe for or purchase any securities of Molecular Partners AG. This publication may contain certain forward-looking statements and assessments or intentions concerning the company and its business. Such statements involve certain risks, uncertainties and other factors which could cause the actual results, financial condition, performance or achievements of the company to be materially different from those expressed or implied by such statements. Readers should therefore not place reliance on these statements, particularly not in connection with any contract or investment decision. The company disclaims any obligation to update these forward-looking statements, assessments or intentions.

Molecular Partners’ strategic partner Allergan completed patient recruitment in both abicipar pegol nAMD Phase 3 studies

Zurich-Schlieren, May 09, 2017. Molecular Partners AG (SIX: MOLN), a clinical-stage biopharmaceutical company that is developing a new class of drugs, known as DARPin® therapies, today announces that its partner Allergan has completed the patient recruitment in the two global AMD Phase 3 studies of abicipar pegol.

“We are impressed by the high recruitment speed that our colleagues from Allergan have accomplished and look forward to the 1-year data to be presented in 2018,” commented Michael T. Stumpp, PhD, Chief Scientific Officer of Molecular Partners.

Patrick Amstutz, PhD, acting CEO of Molecular Partners added: “This is a major milestone for Molecular Partners and the whole DARPin® product pipeline. I would like to congratulate all teams involved, both here at Molecular Partners and at Allergan for this tremendous achievement.”

Abicipar is an investigational drug for the treatment of retinal diseases such as neovascular AMD (nAMD), a leading cause of blindness in the western world. Abicipar may allow for less frequent dosing compared to currently approved anti-VEGF treatments which require monthly or bi-monthly injections into the eye.

The phase 3 program includes two studies, CEDAR and SEQUOIA, each planned to recruit 900 patients. The studies will evaluate the efficacy and safety of abicipar versus ranibizumab (Lucentis®) and the potential of abicipar to be dosed every 8 or 12 weeks vs. ranibizumab every 4 weeks. Top-line data are expected in 2018.

 

About Abicipar

Abicipar is a long-acting mono-DARPin® drug candidate that inhibits vascular endothelial growth factor A (VEGF-A) and is currently under investigation for the treatment of two major causes of blindness worldwide: neovascular AMD (also called wet AMD, wAMD) and diabetic macular edema (DME). Abicipar has the potential to require less frequent injections into the eye than the current anti-VEGF standard of care, while providing equal or better improvements in vision, both seen as major patient benefits in these indications. Molecular Partners exclusively licensed abicipar to Allergan in May 2011.

About the DARPin® Difference

DARPin® therapeutics are a new class of protein therapeutics opening an extra dimension of multi-specificity and multi-functionality. DARPin® candidates are potent, specific, safe and very versatile. They can engaging in more than 5 targets at once, offering potential benefits over those offered by conventional monoclonal antibodies or other currently available protein therapeutics.
The DARPin® technology is a fast and cost-effective drug discovery engine, producing drug candidates with ideal properties for development and very high production yields.

Clinical trials have demonstrated a well-tolerated, low immunogenicity and long half-life in the bloodstream and the eye, DARPin® therapies have the potential to advance modern medicine and significantly improve the treatment of serious diseases, including cancer and sight-threatening disorders. Molecular Partners is partnering with Allergan to advance clinical programs in ophthalmology, and is advancing a proprietary pipeline of DARPin® drug candidates in oncology. The most advanced global product candidate is abicipar, a molecule currently in Phase 3, in partnership with Allergan. The most advanced systemic DARPin® molecule, MP0250, is in clinical development for the treatment of solid tumors and is moving to Phase 2 for hematological and solid tumors. MP0274, the second-most advanced DARPin® drug candidate in oncology, has broad anti-HER activity; it inhibits HER1, HER2 and HER3-mediated downstream signaling via Her2, leading to induction of apoptosis. MP0274 is currently moving in Phase 1. Molecular Partners is also advancing a growing preclinical pipeline that features several immuno-oncological development programs. DARPin® is a registered trademark owned by Molecular Partners AG.

About Molecular Partners AG

Molecular Partners AG is a clinical-stage biopharmaceutical company that is developing a new class of therapies known as DARPin® therapies. With a management team that includes many of the founding scientists, the company continues to attract talented individuals who share the passion to develop breakthrough medicines for serious diseases. Molecular Partners has compounds in various stages of clinical and preclinical development and several more in the research stage, with a current focus on ophthalmology and oncology. The company establishes research and development partnerships with leading pharmaceutical companies and is backed by established biotech investors.

For more information regarding Molecular Partners AG, go to: www.molecularpartners.com.

 

For further details please contact:

Dr. Patrick Amstutz, acting CEO
patrick.amstutz@molecularpartners.com
Tel: +41 (0) 44 755 77 00

Andreas.Emmenegger, CFO
andreas.emmenegger@molecularpartners.com
Tel: +41 (0) 44 755 77 00

Rolf Schläpfer
Hirzel.Neef.Schmid.Counselors
rolf.schlaepfer@konsulenten.ch
Tel: +41 (0) 43 344 42 42

Susan A. Noonan
S.A. Noonan Communications, LLC
susan@sanoonan.com
Tel: +1 212 966 3650

 

Disclaimer

This communication does not constitute an offer or invitation to subscribe for or purchase any securities of Molecular Partners AG. This publication may contain certain forward-looking statements and assessments or intentions concerning the company and its business. Such statements involve certain risks, uncertainties and other factors which could cause the actual results, financial condition, performance or achievements of the company to be materially different from those expressed or implied by such statements. Readers should therefore not place reliance on these statements, particularly not in connection with any contract or investment decision. The company disclaims any obligation to update these forward-looking statements, assessments or intentions.

Quarterly Management Statement for the Period Ending March 31, 2017

Research & Development:

  • MP0250: Phase 2 in multiple myeloma: First patients expected in the coming months. Full regulatory approvals received for Germany, approvals in Poland and Italy expected in the coming weeks
  • MP0250: Additional Phase 2 trial for solid tumor indication to be submitted in 2017;
    targeted indication to be disclosed in Q2 2017
  • MP0274: Regulatory submission ongoing for Phase 1 trial, a multi-specific DARPin® candidate for treatment of HER2-positive solid tumors; Mode of action data presented at AACR Annual Meeting in April 2017
  • Immuno-oncology: Advancement of proprietary programs continues; Further data to be presented at EACR in Florence
  • Abicipar: Phase 3 trials in wet AMD (wet age-related macular degeneration) progress in line with expectations and previous announcements
  • Abicipar: Allergan expected to start Phase 3 trials in DME (diabetic macular edema) in H2 2017

Financial Highlights:

  • Ongoing strong financial position with CHF 169.2 million in cash and short-term time deposits as of March 31, 2017
  • Net cash used in operating activities of CHF 10.1 million in Q1 2017, reflecting scale-up of R&D, pipeline growth and progress of proprietary clinical programs
  • Operating loss of CHF 6.7 million and net loss of CHF 7.6 million in the first quarter

Governance, Team & Other:

  • Talent base with 102 full-time employees, up 9% year-over-year and unchanged compared to year-end 2016, reflecting strengthening of clinical team
  • Gwen Fyfe, MD, to be proposed for election to Board of Directors at Annual General Meeting on May 11, 2017
  • Early April, venture capital investors reduced holding from 42% to 28% of share capital; Private investors acquired shares from venture capitalists in secondary block trades

 

Zurich-Schlieren, May 04, 2017. Molecular Partners AG (SIX: MOLN), a clinical-stage biopharmaceutical company that is developing a new class of drugs, known as DARPin® therapies, today announced its Quarterly Management Statement and key financial highlights for the first quarter ending March 31, 2017.

“We are very pleased with the progress of our DARPin® drug candidates in all therapeutic areas during the first months into 2017. For our lead oncology asset MP0250 we have received full regulatory approvals in Germany to commence our Phase 2 trial. The first patients are expected in the coming months. Moreover, we presented additional data on MP0274 as well as on our growing immune-oncology franchise at the important AACR Annual Meeting in the US,” said Dr. Patrick Amstutz, acting Chief Executive Officer of Molecular Partners. “2017 will be an exciting year for our company. We plan to submit the regulatory package for the second indication for the Phase 2 trial of MP0250 also in 2017. In addition, we expect to start recruitment for our Phase 1 trial of MP0274 in the second half of the year. Finally, in ophthalmology, we are nearing the full enrollment of the abicipar Phase 3 trials in wet-AMD in collaboration with Allergan, a key milestone for our most advanced DARPin® molecule in our pipeline.”

Regulatory approvals received for MP0250 Phase 2

The first Phase 2 study of MP0250 will examine this agent in combination with bortezomib (Velcade®) and dexamethasone in patients with multiple myeloma who have failed standard therapies. This Phase 2 study has been approved in Germany, with first patients entering the study in the coming months. Poland and Italy should receive approval in the coming weeks. Initial safety data are expected in 2017 and efficacy data in 2018.

Second indication for Phase 2 trial of MP0250 to be disclosed in Q2 2017

Given Phase 1 trials of MP0250 had underscored the potential value of MP0250 as a new therapeutic for various tumor types, Molecular Partners will conduct an additional Phase 2 trial for a solid tumor indication. The company will disclose details of this study in Q2 2017.

MP0274 presented at AACR Annual Meeting

In Q1 2017, the regulatory submissions for the Phase 1 trial of MP0274 continued. MP0274 is a proprietary, single-pathway DARPin® drug candidate for the treatment of HER2-positive breast cancer with a completely new mode of action compared to current standard of care antibodies. In an oral presentation on April 04, 2017, at the AACR Annual Meeting the company was able to highlight the unique and distinct inhibition of the HER2 signaling cascade, different from trastuzumab, pertuzumab and a combination of both. As these data show, MP0274 induces a profound inhibition of specific downstream signaling pathways, providing mechanistic support to the finding that MP0274 directly kills HER2-addicted tumor cells through the induction of apoptosis.

Poster for PD-1 / VEGF DARPin® molecule presented at AACR Annual Meeting

In an additional poster presentation at the AACR Annual Meeting, the company was able to present the potential effect of its proprietary multi-specific PD1 and VEGF targeting DARPin® molecule. This DARPin® therapeutic goes beyond targeting PD1 or VEGF alone and hence is expected to offer a strong potential for therapeutic benefit in the clinic, by blocking PD1 and VEGF mediated functions in tumor growth and immunity. The company plans to present further data on its immune-oncology programs at the EACR conference in Florence

Abicipar Phase 3 trials in wet AMD and patient recruitment progress as expected

Patient enrollment in the two Phase 3 trials of abicipar for patients with wet age-related macular degeneration (wet AMD) continues to progress in line with expectations. One-year efficacy data from the two Phase 3 abicipar trials continue to be expected for 2018.

Phase 3 trials for DME to start in H2 2017

Allergan has reconfirmed the previously announced plan to start a Phase 3 trial of abicipar for DME in H2 2017. This Phase 3 trial will use an updated formulation compared to the phase 2 trial.

Financial highlights: Ongoing strong position

In the first quarter of 2017, Molecular Partners recognized total revenues of CHF 3.1 million (Q1 2016: CHF 6.8 million) and incurred operating expenses of CHF 9.8 million (Q1 2016: CHF 9.0 million). This led to an operating loss of CHF 6.7 million for the quarter (Q1 2016: operating loss of CHF 2.2 million). The company recognized net financing expenses of CHF 0.9 million (Q1 2016: net financing expenses of CHF 2.0 million), mainly driven by negative FX effects on USD and EUR cash positions. This resulted in a net loss of CHF 7.6 million for the first quarter 2017 (Q1 2016: net loss of CHF 4.2 million).

The net cash used from operating activities during the first quarter 2017 was CHF 10.1 million (Q1 2016: net cash used of CHF 7.2 million). Including the time deposits, the cash and cash equivalents position of the company decreased by CHF 11.0 million versus year-end 2016 to CHF 169.2 million as of March 31, 2017 (December 31, 2016: CHF 180.2 million). The total shareholders’ equity position decreased to CHF 129.3 million as of March 31, 2017 (December 31, 2016: CHF 135.8 million).

As of March 31, 2017, the company employed 102 FTEs, about 90% of whom are employed in R&D functions (December 31, 2016: 103 FTEs).

Key figures as of March 31, 2017

Key Financials (unaudited)
(CHF million, except per share, FTE data)
Q1 2017 Q1 2016 change
Total revenues 3.1 6.8 -3.7
R&D expenses -8.0 -7.5 -0.5
G&A expenses -1.8 -1.5 -0.3
Operating result -6.7 -2.2 -4.5
Net financial result -0.9 -2.0 1.1
Net result -7.6 -4.2 -3.4
Basic net result per share (in CHF) -0.37 -0.21 -0.16
Net cash from (used in) operating activities -10.1 -7.2 -2.9
Cash balance (incl. time deposits) as of March 31 169.2 205.9 -36.7
Total shareholders’ equity as of March 31 129.3 147.0 -17.7
Number of total FTE as of March 31 102.0 93.7 8.3
– thereof in R&D 91.4 85.5 5.9
– thereof in G&A 10.6 8.2 2.4

“During the first three months in 2017, Molecular Partners’ financial position continued to develop fully in line with our expectations,” said Andreas Emmenegger, Chief Financial Officer of Molecular Partners. “Our ongoing strong cash position continues to provide us with the financial flexibility and a forecasted cash runway until at least end of 2019 – well beyond our key value inflection points.”

Substantial change in shareholder base: Private investors buy stake from venture capitalists

After the end of the first quarter, on April 06, 2017, the company disclosed a substantial change in its shareholders base: Index Ventures Funds fell below 10% to 8.18%, Essex Woodlands Health Ventures Funds, below 10% to 7.82%, and Johnson & Johnson Innovation, below 5% to 4.25%. As a result, the shareholding of Molecular Partners’ venture capital investors was reduced to 28% of the company’s share capital. Several private investors acquired these shares from the venture capitalist investors in secondary block trades.

“We are pleased to report the continued evolution of our shareholder base as we progress our pipeline of innovative DARPin® therapies towards multiple value inflection points in 2018 and beyond. We are grateful for the continued support of our long-term investors who recognized the clinical and commercial potential of our DARPin® platform more than a decade ago,” said Patrick Amstutz, acting Chief Executive Officer of Molecular Partners.

Business outlook and priorities

For the company’s proprietary oncology pipeline, initial safety data from the Phase 2 trial of MP0250 in patients with multiple myeloma (MM) and other serious cancers are expected in 2017 and efficacy data in 2018. In Q2 2017, the company will disclose further details as well as the targeted solid tumor indication for the additional Phase 2 trial of MP0250. With respect to MP0274, a proprietary, single-pathway DARPin® drug candidate for the treatment of HER2-positive breast cancer, the company will initiate the corresponding Phase 1 trial in 2017.

The company will continue to advance its immuno-oncology pipeline and will present further research data in 2017. In this attractive field, Molecular Partners has demonstrated the potential utility of targeting immune checkpoint modulators (ICMs) via combination therapy (e.g., simultaneous inhibition of PD-1 and VEGF) or activating agonists in a tumor-restricted way.

In ophthalmology, Molecular Partners will continue to support its strategic partner Allergan in advancing abicipar through Phase 3 trials in patients with wet AMD and in initiating in H2 2017 the Phase 3 trials of abicipar in patients with DME, the next logical retinal indication.

Financial outlook 2017

Molecular Partners reiterates all elements of the financial outlook 2017 as provided in the company’s 2016 full-year results on February 9, 2017.

For the full year 2017, at constant exchange rates, the company expects total expenses of around CHF 50-60 million, of which around CHF 6 million will be non-cash effective costs for share-based payments, IFRS pension accounting and depreciations. However, this guidance is subject to the progress of the pipeline, mainly driven by manufacturing costs, the speed of enrollment of patients in clinical trials and data from research and development projects. Additionally, the company expects around CHF 2 million of capital expenditures, mainly for laboratory equipment.

No guidance can be provided with regard to net cash flow projections. Timelines and potential milestone payments for existing and potentially new partnerships are not disclosed.

 

Financial Calendar

May 11, 2017 Annual General Meeting
August 30, 2017 Publication of 2017 Half-year Results
October 26, 2017 Q3 2017 Management Statement

http://investors.molecularpartners.com/financial-calendar-and-events/

 

About the DARPin® Difference

DARPin® therapeutics are a new class of protein therapeutics opening an extra dimension of multi-specificity and multi-functionality. DARPin® candidates are potent, specific, safe and very versatile. They can engaging in more than 5 targets at once, offering potential benefits over those offered by conventional monoclonal antibodies or other currently available protein therapeutics. The DARPin® technology is a fast and cost-effective drug discovery engine, producing drug candidates with ideal properties for development and very high production yields.

With their good safety profile, low immunogenicity and long half-life in the bloodstream and the eye, DARPin® therapies have the potential to advance modern medicine and significantly improve the treatment of serious diseases, including cancer and sight-threatening disorders. Molecular Partners is partnering with Allergan to advance clinical programs in ophthalmology, and is advancing a proprietary pipeline of DARPin® drug candidates in oncology. The most advanced global product candidate is abicipar, a molecule currently in Phase 3, in partnership with Allergan. Several DARPin® molecules for various ophthalmic indications are also in development. The most advanced systemic DARPin® molecule, MP0250, is in Phase 1 clinical development for the treatment of solid tumors and moves into Phase 2 for hematological and later for solid tumors. MP0274, the second-most advanced DARPin® drug candidate in oncology, has broad anti-HER activity; it inhibits HER1, HER2 and HER3-mediated downstream signaling via Her2, leading to induction of apoptosis. MP0274 is currently moving in Phase 1. Molecular Partners is also advancing a growing preclinical pipeline that features several immuno-oncological development programs. DARPin® is a registered trademark owned by Molecular Partners AG.

About Molecular Partners AG

Molecular Partners AG is a clinical-stage biopharmaceutical company that is developing a new class of therapies known as DARPin® therapies. With a management team that includes many of the founding scientists, the company continues to attract talented individuals who share the passion to develop breakthrough medicines for serious diseases. Molecular Partners has compounds in various stages of clinical and preclinical development and several more in the research stage, with a current focus on ophthalmology and oncology. The company establishes research and development partnerships with leading pharmaceutical companies and is backed by established biotech investors.

For more information regarding Molecular Partners AG, go to: www.molecularpartners.com.

 

For further details please contact:

Dr. Patrick Amstutz, acting CEO
patrick.amstutz@molecularpartners.com
Tel: +41 (0) 44 755 77 00

Andreas.Emmenegger, CFO
andreas.emmenegger@molecularpartners.com
Tel: +41 (0) 44 755 77 00

Rolf Schläpfer
Hirzel.Neef.Schmid.Counselors
rolf.schlaepfer@konsulenten.ch
Tel: +41 (0) 43 344 42 42

Susan A. Noonan
S.A. Noonan Communications, LLC
susan@sanoonan.com
Tel: +1 212 966 3650

 

Disclaimer

This communication does not constitute an offer or invitation to subscribe for or purchase any securities of Molecular Partners AG. This publication may contain certain forward-looking statements and assessments or intentions concerning the company and its business. Such statements involve certain risks, uncertainties and other factors which could cause the actual results, financial condition, performance or achievements of the company to be materially different from those expressed or implied by such statements. Readers should therefore not place reliance on these statements, particularly not in connection with any contract or investment decision. The company disclaims any obligation to update these forward-looking statements, assessments or intentions.

Molecular Partners Publishes Invitation to Annual General Meeting 2017

Zurich-Schlieren, April 13, 2017. Molecular Partners AG (SIX: MOLN), a clinical-stage biopharmaceutical company that is developing a new class of drugs, known as DARPin® therapies, today published the Invitation to the Annual General Meeting 2017.

The Annual General Meeting will be held on Thursday, May 11, 2017, 2.00 pm CET (doors open at 1.00 pm), at the SIX Swiss Exchange Convention Point Conference Center, Room Exchange, Selnaustrasse 30, 8021 Zurich.

Link to the Invitation to the Annual General Meeting 2017 with the corresponding agenda items.

Link zur Einladung zur Generalversammlung 2017 mit den zugehörigen Traktandenpunkten.

 

Financial Calendar

May 4, 2017 Q1 2017 Management Statement
May 11, 2017 Annual General Meeting
August 30, 2017 Publication of 2017 Half-year Results
October 26, 2017 Q3 2017 Management Statement

http://investors.molecularpartners.com/financial-calendar-and-events/

 

About Molecular Partners AG

Molecular Partners AG is a clinical-stage biopharmaceutical company that is developing a new class of therapies known as DARPin® therapies. With a management team that includes many of the founding scientists, the company continues to attract talented individuals who share the passion to develop breakthrough medicines for serious diseases. Molecular Partners has compounds in various stages of clinical and preclinical development and several more in the research stage, with a current focus on ophthalmology and oncology. The company establishes research and development partnerships with leading pharmaceutical companies and is backed by established biotech investors.

For more information regarding Molecular Partners AG, go to: www.molecularpartners.com.

 

For further details please contact:

Dr. Patrick Amstutz, acting CEO
patrick.amstutz@molecularpartners.com
Tel: +41 (0) 44 755 77 00

Andreas.Emmenegger, CFO
andreas.emmenegger@molecularpartners.com
Tel: +41 (0) 44 755 77 00

Rolf Schläpfer
Hirzel.Neef.Schmid.Counselors
rolf.schlaepfer@konsulenten.ch
Tel: +41 (0) 43 344 42 42

S.A. Noonan
Susan A. Noonan Communications, LLC
susan@sanoonan.com
Tel: +1 212 966 3650

 

Disclaimer

This communication does not constitute an offer or invitation to subscribe for or purchase any securities of Molecular Partners AG. This publication may contain certain forward-looking statements and assessments or intentions concerning the company and its business. Such statements involve certain risks, uncertainties and other factors which could cause the actual results, financial condition, performance or achievements of the company to be materially different from those expressed or implied by such statements. Readers should therefore not place reliance on these statements, particularly not in connection with any contract or investment decision. The company disclaims any obligation to update these forward-looking statements, assessments or intentions.

Christian Zahnd appointed as Honorary Chairman of the Board of Directors as he decided not to stand for re-election as member of the Board of Directors at the Annual General Meeting 2017

Zurich-Schlieren, April 12, 2017. Molecular Partners AG (SIX: MOLN), a clinical-stage biopharmaceutical company developing a new class of drugs known as DARPin®* therapies, today announces that Christian Zahnd,  co-founder and former CEO of the company, has decided not to stand for re-election as member of the Board of Directors at the Annual General Meeting 2017 due to health reasons.

In recognition of his immense contribution to the company, the Board of Directors has decided to appoint him as Honorary Chairman of the Board of Directors of Molecular Partners AG.

“It has been an extraordinary privilege to work with Christian over the past 12 years. Christian led the company to where it is today and his commitment and charisma have been instrumental for the company’s success,” said Joern Aldag, Chairman of the Board of Directors.

 

About Molecular Partners AG

Molecular Partners AG is a clinical-stage biopharmaceutical company that is developing a new class of therapies known as DARPin® therapies. With a management team that includes many of the founding scientists, the company continues to attract talented individuals who share the passion to develop breakthrough medicines for serious diseases. Molecular Partners has compounds in various stages of clinical and preclinical development and several more in the research stage, with a current focus on ophthalmology and oncology. The company establishes research and development partnerships with leading pharmaceutical companies and is backed by established biotech investors.

For more information regarding Molecular Partners AG, go to: www.molecularpartners.com.

 

For further details please contact:

Dr. Patrick Amstutz, acting CEO
patrick.amstutz@molecularpartners.com
Tel: +41 (0) 44 755 77 00

Andreas.Emmenegger, CFO
andreas.emmenegger@molecularpartners.com
Tel: +41 (0) 44 755 77 00

Rolf Schläpfer
Hirzel.Neef.Schmid.Counselors
rolf.schlaepfer@konsulenten.ch
Tel: +41 (0) 43 344 42 42

S.A. Noonan
Susan A. Noonan Communications, LLC
susan@sanoonan.com
Tel: +1 212 966 3650

 

Disclaimer

This communication does not constitute an offer or invitation to subscribe for or purchase any securities of Molecular Partners AG. This publication may contain certain forward-looking statements and assessments or intentions concerning the company and its business. Such statements involve certain risks, uncertainties and other factors which could cause the actual results, financial condition, performance or achievements of the company to be materially different from those expressed or implied by such statements. Readers should therefore not place reliance on these statements, particularly not in connection with any contract or investment decision. The company disclaims any obligation to update these forward-looking statements, assessments or intentions.

Molecular Partners discloses change in shareholder base

  • Long-term venture capital investors holding reduced to 28% of share capital
  • Private investors acquired shares from venture capitalist investors in secondary block trades

Zurich-Schlieren, April 6, 2017. Molecular Partners AG (SIX: MOLN), a clinical-stage biopharmaceutical company that is developing a new class of drugs, known as DARPin® therapies, today reported changes in ownership based on disclosure notifications received according to Article 120 of the Swiss Financial Market Infrastructure Act. According to such disclosure notifications, three investors crossed the following thresholds on April 5, 2017: Index Ventures Funds fell below 10% to 8.18%; Essex Woodlands Health Ventures Funds, below 10% to 7.82%, and Johnson & Johnson Innovation, below 5% to 4.25%. Private investors acquired shares from venture capitalist investors in secondary block trades.

“We are pleased to report the continued evolution of our shareholder base as we advance innovative DARPin® therapies to benefit patients. We are grateful for the continued support of long-term investors who recognized the clinical and commercial potential of our DARPin® platform more than a decade ago,” said Patrick Amstutz, acting Chief Executive Officer of Molecular Partners. “The natural rotation of our shareholder base enables the continued progress of Molecular Partners as we approach multiple value inflection points in 2018 and beyond, including the anticipated one-year readout of the efficacy data from two Phase 3 clinical trials of abicipar, our lead compound for wet age-related macular degeneration being developed in partnership with Allergan and the initial readout of our proprietary MP0250 study in multiple myeloma and an additional solid tumor indication.”

Financial Calendar

April 13, 2017 Expected Publication of Invitation the Annual General Meeting 2017
May 4, 2017 Q1 2017 Management Statement
May 11, 2017 Annual General Meeting
August 30, 2017 Publication of 2017 Half-year Results
October 26, 2017 Q3 2017 Management Statement

http://investors.molecularpartners.com/financial-calendar-and-events/

 

About Molecular Partners AG

Molecular Partners AG is a clinical-stage biopharmaceutical company that is developing a new class of therapies known as DARPin® therapies. With a management team that includes many of the founding scientists, the company continues to attract talented individuals who share the passion to develop breakthrough medicines for serious diseases. Molecular Partners has compounds in various stages of clinical and preclinical development and several more in the research stage, with a current focus on ophthalmology and oncology. The company establishes research and development partnerships with leading pharmaceutical companies and is backed by established biotech investors.

For more information regarding Molecular Partners AG, go to: www.molecularpartners.com.

 

For further details please contact:

Dr. Patrick Amstutz, acting CEO
patrick.amstutz@molecularpartners.com
Tel: +41 (0) 44 755 77 00

Andreas.Emmenegger, CFO
andreas.emmenegger@molecularpartners.com
Tel: +41 (0) 44 755 77 00

Rolf Schläpfer
Hirzel.Neef.Schmid.Counselors
rolf.schlaepfer@konsulenten.ch
Tel: +41 (0) 43 344 42 42

S.A. Noonan
Susan A. Noonan Communications, LLC
susan@sanoonan.com
Tel: +1 212 966 3650

 

Disclaimer

This communication does not constitute an offer or invitation to subscribe for or purchase any securities of Molecular Partners AG. This publication may contain certain forward-looking statements and assessments or intentions concerning the company and its business. Such statements involve certain risks, uncertainties and other factors which could cause the actual results, financial condition, performance or achievements of the company to be materially different from those expressed or implied by such statements. Readers should therefore not place reliance on these statements, particularly not in connection with any contract or investment decision. The company disclaims any obligation to update these forward-looking statements, assessments or intentions.