Molecular Partners’ Strategic Partner Allergan to Present Abicipar Phase 2 Data of PALM Study in Diabetic Macular Edema (DME) at the 2016 AAO Annual Meeting

Molecular Partners’ Strategic Partner Allergan to Present Abicipar Phase 2 Data of PALM Study in Diabetic Macular Edema (DME) at the 2016 AAO Annual Meeting

Zurich‐Schlieren and Dublin, Ireland, October 10, 2016. Molecular Partners AG (SIX: MOLN) and Allergan (NYSE: AGN) today announced that Tarek S. Hassan, MD, Professor of Ophthalmology at Oakland University William Beaumont School of Medicine and Senior Partner and Director of the Vitreoretinal Fellowship Training Program at Associated Retinal Consultants in Royal Oak, Michigan, will present the data of PALM, A Multicenter, Double Masked Phase 2 Clinical Trial Evaluating Abicipar Pegol for Diabetic Macular Edema on Saturday, October 15, 2016 at 11:27 AM Central Time during the 2016 American Academy of Ophthalmology Annual Meeting (AAO) in Chicago.

About Abicipar

Abicipar is a long-acting mono-DARPin® drug candidate that inhibits vascular endothelial growth factor A (VEGF-A) and is currently under investigation for the treatment of two major causes of blindness worldwide: neovascular, or wet age-related macular degeneration (wet AMD) and diabetic macular edema (DME). Abicipar has the potential to require less frequent injections into the eye than the current anti-VEGF standards of care, while providing equal or better improvements in vision, both seen as mayor patient benefits in these indications. Molecular Partners exclusively licensed Abicipar to Allergan in May 2011.

About the DARPin® technology

Molecular Partners is progressing programs in ophthalmology in partnership with Allergan and in oncology with a proprietary pipeline of DARPin® drug candidates. The most advanced assets globally is abicipar, a molecule currently in phase 3 which is being advanced by Allergan. Abicipar is being followed by several DARPin® proteins for various ophthalmic indications. The most advanced systemic DARPin® molecule, MP0250, is in clinical development for solid tumors and is moving to phase 2 for hematological and solid tumors. The second most advanced oncology DARPin® drug candidate is MP0274, which has broad anti-HER activity, inhibiting HER1, HER2, and HER3-mediated downstream signaling via Her2 and leading to induction of apoptosis. MP0274 is currently in preclinical development. There is a growing pipeline of immune-oncological treatments following the two proprietary lead assets.

About Molecular Partners AG

Molecular Partners AG is a clinical-stage biopharmaceutical company that is developing a new, class of therapies known as DARPin® therapies. DARPin® therapies are potent, specific, and versatile small proteins, which have the potential to offer benefits over conventional monoclonal antibodies or other currently available protein therapeutics. The DARPin® technology has the potential to offer a multi-specific approach to treatment, which enables the DARPin® therapies to target multiple pathways, or multiple epitopes on a single target to achieve substantial patient benefit. DARPin® therapies have the potential to advance modern medicine and significantly improve the treatment of serious diseases, including cancer and sight-threatening disorders. DARPin® is a registered trademark owned by Molecular Partners AG.

Molecular Partners has four compounds in various stages of clinical and preclinical development and several more in the research stage, with a current focus on ophthalmology and oncology. The company establishes research and development partnerships with leading pharmaceutical companies and is backed by established biotech investors.

For more information regarding Molecular Partners AG, go to: www.molecularpartners.com.

About Allergan

Allergan plc (NYSE: AGN), headquartered in Dublin, Ireland, is a bold, global pharmaceutical com-pany and a leader in a new industry model – Growth Pharma.  Allergan is focused on developing, manufacturing and commercializing branded pharmaceuticals, devices and biologic products for patients around the world.

Allergan markets a portfolio of leading brands and best-in-class products for the central nervous system, eye care, medical aesthetics and dermatology, gastroenterology, women’s health, urology and anti-infective therapeutic categories.

Allergan is an industry leader in Open Science, the Company’s R&D model, which defines the company’s approach to identifying and developing game-changing ideas and innovation for better patient care. This approach has led to Allergan building one of the broadest development pipelines in the pharmaceutical industry with 65+ mid-to-late stage pipeline programs in development.

Allergan’s success is powered by the company’s more than 16,000 global colleagues’ commitment to being Bold for Life. Together, the company builds bridges, powers ideas, acts fast and drives results for its customers and patients around the world by always doing what is right.

With commercial operations in approximately 100 countries, Allergan is committed to working with physicians, healthcare providers and patients to deliver innovative and meaningful treat-ments that help people around the world live longer, healthier lives every day.

For more information, visit Allergan’s website at www.Allergan.com.

 

For further details please contact:

Dr. Christian Zahnd, CEO
christian.zahnd@molecularpartners.com
Tel: +41 (0) 44 755 77 00

PD Dr. Andreas Harstrick, CMO
andreas.harstrick@molecularpartners.com
Tel: +41 (0) 44 755 77 00

Rolf Schläpfer
Hirzel.Neef.Schmid.Counselors
rolf.schlaepfer@konsulenten.ch
Tel: +41 (0) 43 344 42 42

S.A. Noon
Susan A. Noonan Communications, LLC
susan@sanoonan.com
Tel: +1 212 966 3650

 

Disclaimer

This communication does not constitute an offer or invitation to subscribe for or purchase any securities of Molecular Partners AG. This publication may contain certain forward-looking statements and assessments or intentions concerning the Company and its business. Such statements involve certain risks, uncertainties and other factors which could cause the actual results, financial condition, performance or achievements of the Company to be materially different from those expressed or implied by such statements. Readers should therefore not place reliance on these statements, particularly not in connection with any contract or investment decision. The Company disclaims any obligation to update these forward-looking statements, assessments or intentions.

Molecular Partners Presents Data of MP0250 in an All-Comer Phase 1-Study in Solid Tumor Patients and Updates on Phase 2 Studies

Zurich‐Schlieren, October 9, 2016. Molecular Partners AG (SIX: MOLN), a clinical-stage biopharmaceutical company that is developing a powerful new class of therapies known as DARPin® therapies, announces additional details about its ongoing clinical oncology program MP0250.

M.R. Middleton, Professor of Experimental Cancer Medicine, Department of Oncology at the University of Oxford, UK presents today the completed phase 1 dose escalation interim results of MP0250 at the poster session ‘Developmental Therapeutics’ at the Conference of the European Society of Medical Oncology (ESMO).  The poster is available under this link.

MP0250 is a multi-DARPin® product consisting of four domains targeting vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) and also binds to human serum albumin (HSA) to increase the plasma half-life and potentially tissue penetration.

Prof. M.R. Middleton commented:  “MP0250 used as single agent is the first DARPin® drug candidate to be studied in humans as systemic treatment. The drug is generally well tolerated and the side effect profile is consistent with profound inhibition of the VEGF pathway. We have seen encouraging signs of clinical activity in these heavily pretreated patients, with two patients showing significant reduction of tumor burden and 6 patients having prolonged stable disease. MP0250 has the potential to become a new therapeutic in treating various tumor types.”

These data, now based on the total enrollment of 24 patients, are an important milestone in the development of DARPin® proteins as anticancer agents and expand the results that were published at the AACR-NCI-EORTC conference in November 2015:

  • MP0250 was well tolerated at the higher dose levels (up to 8 mg/kg administered every 2 weeks). This was assigned as the maximally tolerated dose (MTD). Toxicities came primarily from the inhibition of VEGF, including dose-limiting toxicities of acute left ventricular failure, nephrotic syndrome and hypertension, gastrointestinal hemorrhage and thrombotic microangiopathy.
  • MP0250 had a half-life of about 12 days and shows full exposure in all patients over the whole treatment period at all doses.

Update on phase 2 strategy for MP0250

The first phase 2 study will examine MP0250 in combination with bortezomib and dexamethasone in patients with multiple myeloma who have failed proteasome and IMiD based standard therapies. The first regulatory submission for such study is planned in Q4 2016.

Based on the encouraging data from phase 1 in solid tumors, Molecular Partners decided to initiate an additional phase 2 study for a solid tumor indication. Study details will be disclosed in H1 2017.

 

About the DARPin® technology

Molecular Partners is progressing programs in ophthalmology in partnership with Allergan and in oncology with a proprietary pipeline of DARPin® drug candidates. The most advanced assets globally is abicipar, a molecule currently in phase 3 which is being advanced by Allergan. Abicipar is being followed by several DARPins® for various ophthalmic indications. The most advanced systemic DARPin® molecule, MP0250, is in clinical development for solid tumors and is moving to phase 2 for hematological and solid tumors. The second most advanced oncology DARPin® drug candidate is MP0274, which has broad anti-HER activity, inhibiting HER1, HER2, and HER3-mediated downstream signaling via Her2 and leading to induction of apoptosis. MP0274 is currently in preclinical development. There is a growing pipeline of immune-oncological treatments following the two proprietary lead assets.

About Molecular Partners AG

Molecular Partners AG is a clinical-stage biopharmaceutical company that is developing a new, class of therapies known as DARPin® therapies. DARPin® therapies are potent, specific, and versatile small proteins, which have the potential to offer benefits over conventional monoclonal antibodies or other currently available protein therapeutics. The DARPin® technology has the potential to offer a multi-specific approach to treatment, which enables the DARPin® therapies to target multiple pathways, or multiple epitopes on a single target to achieve substantial patient benefit. DARPin® therapies have the potential to advance modern medicine and significantly improve the treatment of serious diseases, including cancer and sight-threatening disorders. DARPin® is a registered trademark owned by Molecular Partners AG.

Molecular Partners has four compounds in various stages of clinical and preclinical development and several more in the research stage, with a current focus on ophthalmology and oncology. The company establishes research and development partnerships with leading pharmaceutical companies and is backed by established biotech investors.

For more information regarding Molecular Partners AG, go to: www.molecularpartners.com.

 

For further details please contact:

Dr. Christian Zahnd, CEO
christian.zahnd@molecularpartners.com
Tel: +41 (0) 44 755 77 00

PD Dr. Andreas Harstrick, CMO
andreas.harstrick@molecularpartners.com
Tel: +41 (0) 44 755 77 00

Rolf Schläpfer
Hirzel.Neef.Schmid.Counselors
rolf.schlaepfer@konsulenten.ch
Tel: +41 (0) 43 344 42 42

S.A. Noon
Susan A. Noonan Communications, LLC
susan@sanoonan.com
Tel: +1 212 966 3650

 

Disclaimer

This communication does not constitute an offer or invitation to subscribe for or purchase any securities of Molecular Partners AG. This publication may contain certain forward-looking statements and assessments or intentions concerning the Company and its business. Such statements involve certain risks, uncertainties and other factors which could cause the actual results, financial condition, performance or achievements of the Company to be materially different from those expressed or implied by such statements. Readers should therefore not place reliance on these statements, particularly not in connection with any contract or investment decision. The Company disclaims any obligation to update these forward-looking statements, assessments or intentions.

Molecular Partners Regains Rights to Multi-DARPin® Drug Candidate Targeting IL-13 & IL-17 for Pulmonary Indications from Janssen

Zurich‐Schlieren, October 6, 2016. Molecular Partners AG (SIX: MOLN), a clinical-stage biopharmaceutical company that is developing a powerful new class of therapies known as DARPin® therapies, regained the full rights to a multi-DARPin® drug candidate targeting both IL-13 and IL-17 with long systemic half-life and potential use in pulmonary indications following the discontinuation of a Collaboration and License Agreement entered into with Janssen Biotech, Inc. (Janssen) in 2011.

Under the collaboration, Molecular Partners and Janssen and generated a multi-DARPin® drug candidate that is ready to enter into preclinical development. The research and development costs of this drug candidate were supported by Janssen.

“We are proud to have successfully applied our DARPin® platform to generate this highly differentiated multi-DARPin® drug candidate for Janssen, and respect their strategic decision not related to the DARPIN® drug candidate. Molecular Partners will thoroughly evaluate if this drug candidate should be added to our proprietary pipeline, partnered or discontinued,” said Dr. Christian Zahnd, Chief Executive Officer of Molecular Partners.

The termination of the collaboration with Janssen in immunology does not impact Molecular Partners‘ strategy. Molecular Partners is progressing programs in ophthalmology in partnership with Allergan and in oncology with a proprietary pipeline of DARPin® drug candidates. The most advanced programs are Abicipar currently in phase 3 and MP0250 which is moving into phase 2 clinical studies in hematological malignancies.

 

About Molecular Partners AG

Molecular Partners AG is a clinical-stage biopharmaceutical company that is developing a new, class of therapies known as DARPin® therapies. DARPin® therapies are potent, specific, and versatile small proteins, which have the potential to offer benefits over conventional monoclonal antibodies or other currently available protein therapeutics. The DARPin® technology has the potential to offer a multi-specific approach to treatment, which enables the DARPin® therapies to target multiple pathways, or multiple epitopes on a single target to achieve substantial patient benefit. DARPin® therapies have the potential to advance modern medicine and significantly improve the treatment of serious diseases, including cancer and sight-threatening disorders. DARPin® is a registered trademark owned by Molecular Partners AG.

Molecular Partners has four compounds in various stages of clinical and preclinical development and several more in the research stage, with a current focus on ophthalmology and oncology. The company establishes research and development partnerships with leading pharmaceutical companies and is backed by established biotech investors.

For more information regarding Molecular Partners AG, go to: www.molecularpartners.com.

 

For further details, please contact:
Dr. Christian Zahnd, CEO
christian.zahnd@molecularpartners.com
Tel: +41 (0) 44 755 77 00

Dr. Patrick Amstutz, COO
patrick.amstutz@molecularpartners.com
Tel: +41 (0) 44 755 77 00

Rolf Schläpfer
Hirzel.Neef.Schmid.Counselors
rolf.schlaepfer@konsulenten.ch
Tel: +41 (0) 43 344 42 42

S.A. Noon
Susan A. Noonan Communications, LLC
susan@sanoonan.com
Tel: +1 212 966 3650

 

Disclaimer

This communication does not constitute an offer or invitation to subscribe for or purchase any securities of Molecular Partners AG. This publication may contain certain forward-looking statements and assessments or intentions concerning the Company and its business. Such statements involve certain risks, uncertainties and other factors which could cause the actual results, financial condition, performance or achievements of the Company to be materially different from those expressed or implied by such statements. Readers should therefore not place reliance on these statements, particularly not in connection with any contract or investment decision. The Company disclaims any obligation to update these forward-looking statements, assessments or intentions.

Molecular Partners to Present the Completed Phase I Dose Escalation Interim Results of MP0250 at the Annual ESMO Congress in Copenhagen

Zurich-Schlieren, September 28, 2016. Molecular Partners AG (SIX: MOLN), a clinical-stage biopharmaceutical company that is developing a new class of therapies, known as DARPin® therapies, today announced that M.R. Middleton, MD at the Churchill Hospital, Oxford, UK will present interim data of the completed dose escalation, part of the MP0250 Phase I study, at the annual ESMO congress in Copenhagen on October 9th, 2016 at 3.00 PM CET.

The corresponding abstract is available on the ESMO webpage.

MP0250 is a multi- DARPin® product consisting of four domains targeting vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) and also binds to human serum albumin (HSA) to increase the plasma half-life and potentially tissue penetration.

About Molecular Partners AG
Molecular Partners AG is a clinical-stage biopharmaceutical company that is developing a new, class of therapies known as DARPin® therapies. DARPin® therapies are potent, specific, and versatile small proteins, which have the potential to offer benefits over conventional monoclonal antibodies or other currently available protein therapeutics. The DARPin® technology has the potential to offer a multi-specific approach to treatment, which enables the DARPin® therapies to target multiple pathways, or multiple epitopes on a single target to achieve substantial patient benefit. DARPin® therapies have the potential to advance modern medicine and significantly improve the treatment of serious diseases, including cancer and sight-threatening disorders. DARPin® is a registered trademark owned by Molecular Partners AG.

Molecular Partners has four compounds in various stages of clinical and preclinical development and several more in the research stage, with a current focus on ophthalmology and oncology. The company has ongoing research and development partnerships with leading pharmaceutical companies, including Allergan and Janssen, and is backed by established biotech investors.
For more information regarding Molecular Partners AG, go to: www.molecularpartners.com.

For further details, please contact:
Dr. Christian Zahnd, CEO
christian.zahnd@molecularpartners.com
Tel: +41 (0) 44 755 77 00

Andreas Emmenegger, CFO
andreas.emmenegger@molecularpartners.com
Tel: +41 (0) 44 755 77 00

Rolf Schläpfer
Hirzel.Neef.Schmid.Counselors
rolf.schlaepfer@konsulenten.ch
Tel: +41 (0) 43 344 42 42

S.A. Noon
Susan A. Noonan Communications, LLC
susan@sanoonan.com
Tel: +1 212 966 3650

Molecular Partners to Present at the Morgan Stanley Global Healthcare Conference in New York

Zurich-Schlieren, September 07, 2016. Molecular Partners AG (SIX: MOLN), a clinical-stage biopharmaceutical company that is developing a new, class of therapies known as DARPins, today announced that Dr. Christian Zahnd, CEO and Andreas Emmenegger, CFO of Molecular Partners will participate in a fireside chat at the Morgan Stanley Global Healthcare Conference on Monday, September 12, 2016 at 5:25 PM Eastern Time (11:25 PM CET).

The presentation will be available for viewing via live webcast and can be accessed on the day through this link. A replay of the webcast will be made available on the company’s website www.molecularpartners.com under the Investors section. The replay will be available for 180 days following the presentation.

About Molecular Partners AG

Molecular Partners AG is a clinical-stage biopharmaceutical company that is developing a new, class of therapies known as DARPins. DARPins are potent, specific, and versatile small-protein therapies, which have the potential to offer benefits over conventional monoclonal antibodies or other currently available protein therapeutics. The DARPin® technology has the potential to offer a multi-specific approach to treatment, which enables DARPins to target multiple pathways, or multiple epitopes on a single target to achieve substantial patient benefit. DARPins have the potential to advance modern medicine and significantly improve the treatment of serious diseases, including cancer and sight-threatening disorders.

Molecular Partners has four compounds in various stages of clinical and preclinical development and several more in the research stage, with a current focus on ophthalmology and oncology. The company has ongoing research and development partnerships with leading pharmaceutical companies, including Allergan and Janssen, and is backed by established biotech investors. For more information regarding Molecular Partners AG, go to: www.molecularpartners.com.

For further details, please contact:

Dr. Christian Zahnd, CEO
christian.zahnd@molecularpartners.com
Tel: +41 (0) 44 755 77 00

Andreas Emmenegger, CFO
andreas.emmenegger@molecularpartners.com
Tel: +41 (0) 44 755 77 00

Rolf Schläpfer
Hirzel.Neef.Schmid.Counselors
rolf.schlaepfer@konsulenten.ch
Tel: +41 (0) 43 344 42 42

S.A. Noon
Susan A. Noonan Communications, LLC
susan@sanoonan.com
Tel: +1 212 966 3650

Molecular Partners reports unaudited half-year results for 2016: A period of continued progress for Molecular Partners

R&D, Partnerships and Team Highlights:

  • Details of Phase II trial of MP0250, a multi-DARPin®* drug candidate targeting vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF), in combination with bortezomib (Velcade®) and dexamethasone in patients with multiple myeloma (MM), announced
  • Strategic plan announced to expand proprietary immuno-oncology pipeline by naming the first two development programs
  • Abicipar advances further in phase III trials in wet age related macular degeneration (wet AMD) as planned; Allergan publicly reiterated firm commitment to DARPins, shortly after withdrawal of planned merger with Pfizer
  • Appointment of Jeffrey H. Buchalter to the Board of Directors

Financial Highlights:

  • Ongoing strong financial position with CHF 196.3 million cash balance (including short-term time deposits) as of June 30, 2016, down CHF 19.1 million versus December 31, 2015, and up 12% year-over-year
  • Net cash used from operating activities of CHF 17.5 million, up CHF 8.2 million year-on-year, reflecting ongoing scale-up of R&D activities and the growth of the company’s pipeline
  • Operating loss of CHF 8.5 million and net loss of CHF 9.7 million in the first half 2016
  • Talent base with 102 full-time employees, up 23% year-over-year and an increase of 15% compared to year-end 2015, reflecting our focus shift to clinical development expertise

[*DARPin® is a registered trademark owned by Molecular Partners AG.]

 

Zurich-Schlieren, September 1, 2016. Molecular Partners AG (SIX:MOLN), a clinical-stage biopharmaceutical company that is developing a new class of therapies known as DARPins, today announced its unaudited half-year results for 2016, a period marked by the ongoing scale-of of the company’s R&D activities and operations as well as the continued growth of its proprietary pipeline.

“We are very pleased with the development and further fortification of our broad and novel pipeline, based on our innovative DARPin® technology platform, and the ongoing strength of our financial position,” said Dr. Christian Zahnd, Chief Executive Officer of Molecular Partners. “We look forward to continued success, including attainment of additional clinical milestones, in the second half of 2016 and beyond.”

Business highlights first half-year 2016

Phase II strategy for MP0250 in multiple myeloma announced

In January, the company announced plans for a Phase II trial of MP0250, a multi-DARPin® drug candidate targeting vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF), in combination with bortezomib (Velcade®) and dexamethasone in patients with multiple myeloma (MM) who have developed resistance to at least two prior regimens (including bortezomib and an immunomodulatory drug). The Phase II trial is expected to be initiated in the second half of 2016.

The Phase II strategy for MP0250 in MM is largely driven by recent findings that resistance to bortezomib is primarily driven by an upregulation of VEGF and HGF pathways. Thus patients that have an acquired resistance to bortezomib with a combination of MP0250, bortezomib and dexamethasone will be dosed. This is supported by Phase I data that demonstrated good tolerability, favorable pharmacokinetics, and sustained exposure over multiple applications of MP0250 in a preliminary analysis in patients with solid tumors.

Two immuno-oncology development programs revealed

In March, the company announced its strategic plan to expand our immuno-oncology pipeline by naming the first two development programs. The first is for a multi-DARPin® that inhibits the programmed cell death protein 1 (PD-1, a validated immune checkpoint target) and VEGF-A, while also binding to human serum albumin. This tri-functional DARPin® is designed to normalize the tumor vasculature by inhibiting VEGF and increasing tumor-penetration and intra-tumor expansion of effector T-cells. Additionally, the DARPin® binding domain to serum albumin is expected to yield a long half-life and to allow for potentially increased tumor penetration.

The second immuno-oncology program is for the development of a highly specific activator of T-cells in the tumor stroma. It binds to co-stimulatory agonists on the surface of T-cells without activating them when bound in circulation – only once the T-cells enter the tumor microenvironment, the agonist is clustered via the DARPin® having a second specificity for a densely expressed target in the stroma. This selective activation of T-cells is typically not seen for antibodies as they tend to directly cluster agonists through their Fc part and clustering on widespread Fc-receptors.

Abicipar progresses in Phase III trials in wet AMD

Abicipar further advances in Phase III trials in wet age related macular degeneration (wet AMD) as planned. This development was accompanied by a statement from Allergan, the company’s strategic partner in the abicipar development program, reiterating its firm commitment to DARPins and publicly stating that abicipar “continues to progress in clinical development and could be a true game changer for people suffering with this disease by lowering the injection burden significantly.”

Available clinical data suggest that abicipar may enable less frequent injections with equal or better visual outcomes, compared to standard-of-care anti-VEGF therapies. Currently, two large, global Phase III abicipar studies are recruiting patients. Molecular Partners anticipates clinical read-outs from these studies in the summer of 2018.

Allergan is also advancing the other DARPins in our ophthalmology alliance, which includes an earlier-stage multi-DARPin® targeting VEGF and platelet-derived growth factor (PDGF) in wet AMD.

Board of Directors further reinforced

At the Molecular Partners annual general meeting on April 20, 2016, the shareholders of the company elected Jeffrey H. Buchalter, former CEO of Enzon and Ilex Oncology, to the board. Mr. Buchalter has many years of strategic and operational experience, including senior executive positions at Pharmacia, Wyeth, and Schering-Plough. He has deep expertise in commercial positioning and development of therapeutics in oncology and has served as chairman as well as non-executive director of various boards.

Financial Highlights in 1Q 2016: Financial development as expected, ongoing strong position

In the first half of 2016, Molecular Partners recognized 21% higher total revenues of CHF 13.5 million (1H 2015: CHF 11.2 million). As expected, total R&D expenses went up significantly by CHF 6.3 million (+53%) to CHF 18.1 million, mainly due to the increased activities in clinical and preclinical development of the proprietary oncology assets. G&A expenses went up by CHF 0.6 million (+18%) to CHF 3.9 million. Overall, total operating expenses increased by CHF 6.9 million (+46%) to CHF 22.0 million. This led to an operating loss of CHF 8.5 million for the period (1H 2015: operating loss of CHF 3.9million). The company incurred net finance expenses of CHF 1.2 million (1H 2015: net finance expenses of CHF 3.2 million), still mainly the result of negative FX effects on USD and EUR cash positions. This resulted in a net loss of CHF 9.7 million for the first half 2016 (1H 2015: net loss of CHF 7.1 million).

The net cash used from operating activities during the first half 2016 was CHF 17.5 million (1H 2015: net cash used of CHF 9.3 million), an increase of 88% which also reflects the company’s commitment to invest into its proprietary pipeline. Including the time deposits, the cash and cash equivalents position of the company decreased by CHF 19.1 million versus year-end 2015 to CHF 196.3 million as of June 30, 2016 (December 31, 2015: CHF 215.4 million). The total shareholders’ equity position decreased by CHF 10.4 million to CHF 141.4 million as of June 30, 2016 (December 31, 2015: CHF 151.8 million).

On April 14, 2016, the Company announced the successful placement of 1.1 million secondary shares in an accelerated book-building transaction at a price of CHF 27.50 per share. Following the option exercise and transaction, the executive management team holds an increased position of Molecular Partners’ shares compared to the situation before the share placement. As a result of the successful share placement, the number of shares outstanding of the company increased by 5.5% to 20,724,345 per June 30, 2016.

As of June 30, 2016, the company employed 102 FTEs, of whom more than 90% are employed in R&D functions (December 31, 2015: 89 FTEs; June 30, 2015: 83.0 FTEs). In R&D, the number of FTEs grew 23% to 93.4 over the course of the last twelve months (June 30, 2015: 76.1 FTE), underlining the ongoing significant investments into the proprietary pipeline of the company.

Key figures as of June 30, 2016

Key Financials (unaudited)
(CHF million, except per share, FTE data)
1H 2016 1H 2015 change
Total revenues  13.5  11.2  2.3
R&D expenses  -18.1  -11.8  -6.3
G&A expenses  -3.9  -3.3  -0.6
Operating loss  -8.5  -3.9  -4.6
Net loss  -9.7  -7.1  -2.6
Basic net loss per share (in CHF)  -0.48  -0.36  -0.12
Net cash used in operating activities  -17.5  -9.3  -8.2
Cash & cash equivalents as of June 30  176.8  175.6  1.2
Cash balance (incl. time deposits) as of June 30  196.3  175.6  20.7
Total shareholders’ equity as June 30  141.4  143.0  -1.6
Number of total FTE as of June 30  102.4  83.0  19.4
– thereof in R&D  93.4  76.1  17.3
– thereof in G&A  9.0  6.9  2.1

“In the first half-year 2016, Molecular Partners’ financial position continued to develop fully in line with our projections amid the ongoing commitment to invest into value creating proprietary pipeline assets,” said Andreas Emmenegger, Chief Financial Officer of Molecular Partners. “We reiterate our previously provided financial guidance for 2016.”

Business outlook and priorities

For the company’s proprietary oncology pipeline, plans for the second half of 2016 include the initiation of the Phase II trial of MP0250 (in combination with bortezomib and dexamethasone) in patients with MM and initiating a Phase I trial of MP0274, a proprietary, single-pathway DARPin® for the treatment of HER2-positive breast cancer. By providing a broad blockade of HER1, HER2, and HER3-mediated signaling, MP0274 induces apoptosis in HER2-overexpressing cells, with the potential to produce a higher rate of cancer cell death than other approved anti-HER2 targeting molecules, such as Herceptin® (trastuzumab).

The company will also continue to advance the immuno-oncology pipeline, an area in which Molecular Partners has demonstrated the potential utility of targeting immune checkpoint modulators (ICMs) via combination therapy (e.g. joint inhibition of PD-1 and VEGF) or activating agonists while localizing its effects. Molecular Partners sees a lot of potential in ICM-directed therapy to revolutionize anticancer treatment with its unique DARPin® technology. This may also be attractive to potential partners who are active in the immuno-oncology field, though the company may choose to develop these product candidates on a proprietary basis.

In ophthalmology, Molecular Partners will continue to support its strategic partner Allergan in advancing abicipar through Phase III trials in patients with wet AMD, and possibly in initiating Phase III trials of abicipar in patients with DME. Collaboration with Allergan will also continue to advance the anti-VEGF/PDGF multi-DARPin® through preclinical development.

The company will continue to leverage our strategic collaborations by benefiting from its partners’ strong scientific, development, regulatory, and commercial capabilities, while granting them access to Molecular Partners’ biologics expertise and know-how in DARPin® discovery, optimization, and development. The company is also evaluating potential new partnerships based on long-term mutual benefit, particularly in terms of maximizing the value of its product candidates or contributing complementary technologies or capabilities to Molecular Partners.

Additionally, the company will further invest in DARPin® discovery and development to augment its proprietary product pipeline. Capabilities and expertise allow us to quickly identify and progress DARPin® product candidates into clinical development.

By focusing on developing DARPin® product candidates that target validated biological pathways, whether through new combinations or in new therapeutic areas, Molecular Partners can deliver meaningful differentiation from available treatments and increase the probability of success of the company’s development programs.

Financial Outlook 2016

As the first half 2016 developed fully in line with management expectations, Molecular Partners reiterates all elements of the financial outlook 2016 as provided in the company’s 2015 full-year results on February 4, 2016 as well as in the company’s quarterly management statement on April 27, 2016.

For the full year 2016, at constant exchange rates, the company expects total expenses of CHF 50-60 million, of which around CHF 6 million will be non-cash effective costs for share-based payments, IFRS pension accounting and depreciations. However, this may change substantially depending on the progress of the pipeline, mainly driven by the speed of enrollment of patients in clinical trials and data from research and development projects. Additionally, the company expects around CHF 3 million of capital expenditures, mainly for laboratory equipment.

No guidance can be provided with regard to net cash flow projections. Timelines and potential milestone payments for existing and potentially new partnerships cannot be disclosed.

Investor documentation of 1H 2016 results

The 1H 2016 results presentation, the 1H 2016 press release as well as the unaudited Financial Results for 1H 2016 and the company’s 1H 2016 Report and additional information are available on the investors section of the company’ website.

Conference call and audio webcast

Molecular Partners will conduct a conference call and audio webcast of the company’s 1H 2016 results on September 01, 2016, 2:00pm CET (1:00pm GMT, 8:00am EST).
In order to register for the 1H 2016 conference call, please dial the following numbers approximately 10 minutes before the start of the presentation:

Switzerland / Europe                   +41 (0) 58 310 5000

UK                                                    +44 (0) 203 059 5862

USA                                                  +1 (1) 631 570 5613

Participants will have the opportunity to ask questions after the presentation.

The 1H 16 audio webcast will be accessible, both live and as a replay, on the Investors section of the company’s website www.molecularpartners.com, along with the accompanying presentation slides.

Financial Calendar 2016

Publication of Quarterly Management Statement Q3 2016 October 27, 2016
Publication of Full-year Results 2016 (unaudited) February 09, 2017
Expected Publication of Annual Report 2016 March 29, 2017
Annual General Meeting May 11, 2017

About Molecular Partners AG

Molecular Partners AG is a clinical-stage biopharmaceutical company that is developing a new, class of therapies known as DARPins. DARPins are potent, specific, and versatile small-protein therapies, which have the potential to offer benefits over conventional monoclonal antibodies or other currently available protein therapeutics. The DARPin® technology has the potential to offer a multi-specific approach to treatment, which enables DARPins to target multiple pathways, or multiple epitopes on a single target to achieve substantial patient benefit. DARPins have the potential to advance modern medicine and significantly improve the treatment of serious diseases, including cancer and sight-threatening disorders.

Molecular Partners has four compounds in various stages of clinical and preclinical development and several more in the research stage, with a current focus on ophthalmology and oncology. The company has ongoing research and development partnerships with leading pharmaceutical companies, including Allergan and Janssen, and is backed by established biotech investors. For more information regarding Molecular Partners AG, go to: www.molecularpartners.com.

For further details, please contact:

Dr. Christian Zahnd, CEO
christian.zahnd@molecularpartners.com
Tel: +41 (0) 44 755 77 00

Andreas Emmenegger, CFO
andreas.emmenegger@molecularpartners.com
Tel: +41 (0) 44 755 77 00

Rolf Schläpfer
Hirzel.Neef.Schmid.Counselors
rolf.schlaepfer@konsulenten.ch
Tel: +41 (0) 43 344 42 42

S.A. Noon
Susan A. Noonan Communications, LLC
susan@sanoonan.com
Tel: +1 212 966 3650

Disclaimer

This communication does not constitute an offer or invitation to subscribe for or purchase any securities of Molecular Partners AG. This publication may contain certain forward-looking statements and assessments or intentions concerning the Company and its business. Such statements involve certain risks, uncertainties and other factors which could cause the actual results, financial condition, performance or achievements of the Company to be materially different from those expressed or implied by such statements. Readers should therefore not place reliance on these statements, particularly not in connection with any contract or investment decision. The Company disclaims any obligation to update these forward-looking statements, assessments or intentions.

BVF Partners L.P., a US-based investor focused on biotechnology investments, acquired shares from pre-IPO venture capital shareholders

Zurich-Schlieren, July 19, 2016. Molecular Partners AG (ticker: MOLN), a clinical-stage biopharmaceutical company that is developing a new class of therapies known as DARPins, was informed by Biotechnology Value Fund, L.P. and other entities affiliated with BVF Partners L.P. (BVF), a San Francisco-based investor focused on biotechnology, that it holds 4.58% of the voting rights and share capital of Molecular Partners. According to BVF’s declaration dated July 18, 2016 pursuant to Article 120 of the Swiss Financial Market Infrastructure Act, the 3% threshold was crossed on
July 18, 2016.

On July 18, 2016, Molecular Partners was also informed that Index Ventures and Essex Woodlands Health Ventures have fallen below the 15% threshold on the same day.

None of the founders or members of the management team sold any shares in this context.
Christian Zahnd, CEO of Molecular Partners commented: “We are very happy to see that we could gain more interest and support from BVF. We have extensive experience in working together with BVF; their skills and understanding of the long-term value perspective of Molecular Partners makes it a privilege to work with such a highly reputable group.”

Molecular Partners welcome this important step to further expand its long-term oriented specialist investor base.

 

Financial Calendar 2016

Publication of Half-year Results 2016

September 1, 2016

Publication of Quarterly Management Statement Q3 2016

October 27, 2016

http://investors.molecularpartners.com/financial-calendar-and-events/

 

About Molecular Partners AG

Molecular Partners AG is a clinical-stage biopharmaceutical company that is developing a new, class of therapies known as DARPins. DARPins are potent, specific, and versatile small-protein therapies, which have the potential to offer benefits over conventional monoclonal antibodies or other currently available protein therapeutics. The DARPin technology has the potential to offer a multi-specific approach to treatment, which enables DARPins to target multiple pathways, or multiple epitopes on a single target to achieve substantial patient benefit. DARPins have the potential to advance modern medicine and significantly improve the treatment of serious diseases, including cancer and sight-threatening disorders.

Molecular Partners has four compounds in various stages of clinical and preclinical development and several more in the research stage, with a current focus on ophthalmology and oncology. The company has ongoing research and development partnerships with leading pharmaceutical companies, including Allergan and Janssen, and is backed by established biotech investors. For more information regarding Molecular Partners AG, go to: www.molecularpartners.com.

For further details, please contact:

Dr. Christian Zahnd, CEO
christian.zahnd@molecularpartners.com
Tel: +41 (0) 44 755 77 00

Andreas Emmenegger, CFO
andreas.emmenegger@molecularpartners.com
Tel: +41 (0) 44 755 77 00

Rolf Schläpfer
Hirzel.Neef.Schmid.Counselors
rolf.schlaepfer@konsulenten.ch
Tel: +41 (0) 43 344 42 42

 

Disclaimer

This communication does not constitute an offer or invitation to subscribe for or purchase any securities of Molecular Partners AG. This publication may contain certain forward-looking statements and assessments or intentions concerning the company and its business. Such statements involve certain risks, uncertainties and other factors which could cause the actual results, financial condition, performance or achievements of the company to be materially different from those expressed or implied by such statements. Readers should therefore not place reliance on these statements, particularly not in connection with any contract or investment decision. The company disclaims any obligation to update these forward-looking statements, assessments or intentions.

Molecular Partners to Present at the UBS Global Healthcare Conference 2016 in New York

Zurich-Schlieren, May 20, 2016. Molecular Partners AG (ticker: MOLN) today announced that it will present at the UBS Global Healthcare Conference on Tuesday, May 24, 2016 at 2:00 PM Eastern Time (8:00 PM CET). The presentation, followed by a breakout session, will be hosted by Dr.  Christian Zahnd, CEO of Molecular Partners.

The presentation will be available for viewing via live webcast and can be accessed on the day through this link. A copy of the presentation handout as well as a replay of the webcast will be made available on the company’s website www.molecularpartners.com under the Investors section.
The replay will be available for 180 days following the presentation.

 

About Molecular Partners AG

Molecular Partners AG is a clinical-stage biopharmaceutical company that is developing a new, class of therapies known as DARPins. DARPins are potent, specific, and versatile small-protein therapies, which have the potential to offer benefits over conventional monoclonal antibodies or other currently available protein therapeutics. The DARPin technology has the potential to offer a multi-specific approach to treatment, which enables DARPins to target multiple pathways, or multiple epitopes on a single target to achieve substantial patient benefit. DARPins have the potential to advance modern medicine and significantly improve the treatment of serious diseases, including cancer and sight-threatening disorders.

Molecular Partners has four compounds in various stages of clinical and preclinical development and several more in the research stage, with a current focus on ophthalmology and oncology. The company has ongoing research and development partnerships with leading pharmaceutical companies, including Allergan and Janssen, and is backed by established biotech investors. For more information regarding Molecular Partners AG, go to: www.molecularpartners.com.

For further details, please contact:

Dr. Christian Zahnd, CEO
christian.zahnd@molecularpartners.com
Tel: +41 (0) 44 755 77 00

Andreas Emmenegger, CFO
andreas.emmenegger@molecularpartners.com
Tel: +41 (0) 44 755 77 00

Rolf Schläpfer
Hirzel.Neef.Schmid.Counselors
rolf.schlaepfer@konsulenten.ch
Tel: +41 (0) 43 344 42 42

Molecular Partners to Present at the 17th Annual Meeting of Bio€quity Europe 2016 in Copenhagen

Zurich-Schlieren, May 09, 2016. Molecular Partners AG (ticker: MOLN) today announced that it will present at the 17th Annual Meeting of Bio€quity Europe in Copenhagen on Tuesday, May 10, 2016 at 2:00 PM CET.  The presentation will be hosted by Dr. Patrick Amstutz, COO of Molecular Partners.

A copy of the presentation handout will be made available on the company’s website www.molecularpartners.com under the Investors section.

 

About Molecular Partners AG

Molecular Partners AG is a clinical-stage biopharmaceutical company that is developing a new, class of therapies known as DARPins. DARPins are potent, specific, and versatile small-protein therapies, which have the potential to offer benefits over conventional monoclonal antibodies or other currently available protein therapeutics. The DARPin technology has the potential to offer a multi-specific approach to treatment, which enables DARPins to target multiple pathways, or multiple epitopes on a single target to achieve substantial patient benefit. DARPins have the potential to advance modern medicine and significantly improve the treatment of serious diseases, including cancer and sight-threatening disorders.

Molecular Partners has four compounds in various stages of clinical and preclinical development and several more in the research stage, with a current focus on ophthalmology and oncology. The company has ongoing research and development partnerships with leading pharmaceutical companies, including Allergan and Janssen, and is backed by established biotech investors. For more information regarding Molecular Partners AG, go to: www.molecularpartners.com.

 

For further details, please contact:

Dr. Christian Zahnd, CEO
christian.zahnd@molecularpartners.com
Tel: +41 (0) 44 755 77 00

Andreas Emmenegger, CFO
andreas.emmenegger@molecularpartners.com
Tel: +41 (0) 44 755 77 00

Rolf Schläpfer
Hirzel.Neef.Schmid.Counselors
rolf.schlaepfer@konsulenten.ch
Tel: +41 (0) 43 344 42 42

Quarterly Management Statement for the Period Ending March 31, 2016

Phase II strategy for MP0250 laid-out, strategy about immuno-oncology pipeline disclosed, business and financial outlook 2016 fully confirmed

R&D and Operating Highlights:

  • Proprietary oncology pipeline progressing with phase II development plan for lead asset MP0250 in multiple myeloma disclosed
  • Concept for immuno-oncology pipeline and two early-stage programs announced:
    a VEGF/ PD-1 multi-DARPin and tumor-localized agonists
  • Abicipar advances in phase III trials, as strategic partner Allergan reiterated its firm commitment to DARPins

Financial Highlights:

  • Ongoing strong financial position with CHF 205.9 million cash balance (including short-term time deposits) as of March 31, 2016, down CHF 9.5 million versus December 31, 2015, and up 13% year-over-year
  • Net cash used from operating activities of CHF 7.2 million, up CHF 3.4 million year-on-year, reflecting ongoing scale-up of R&D, operational activities and the company’s pipeline
  • Operating loss of CHF 2.2 million and net loss of CHF 4.2 million in the first quarter 2016
  • Growing talent base with 94 full-time employees as of March 31, 2016, up 25% year-over-year and an increase of 5% compared to year-end 2015

Zurich-Schlieren, April 28, 2016. Molecular Partners AG (ticker: MOLN), a clinical-stage biopharmaceutical company that is developing a new class of therapies known as DARPins, today provided its Quarterly Management Statement and key financial highlights for the period ending March 31, 2016.

“We are very pleased with the development and further fortification of our broad and novel pipeline, the renewed commitment of our strategic partners to our innovative DARPin technology platform, as well as the continued strength of our financial position during the first quarter,” said Dr. Christian Zahnd, Chief Executive Officer of Molecular Partners. “We look forward to continue to focus on the remainder of 2016 with several additional milestones expected, including clinical milestones.”

Business highlights in the first quarter 2016

Proprietary oncology pipeline progressing with the phase II development plan for lead asset MP0250 in multiple myeloma disclosed

In the first quarter of 2016, Molecular Partners provided guidance on the Phase II development strategy for MP0250, the lead oncology DARPin. The company will initiate the first Phase II study of this compound in the second half of 2016 in patients with multiple myeloma. The study will investigate MP0250 in combination with bortezomib and dexamethasone in patients whose cancers became refractory while on bortezomib therapy, and who have received at least two prior regimens including bortezomib and an immunomodulatory drug.

Beyond MP0250, Molecular Partners is advancing a growing proprietary pipeline of DARPin therapies. The pipeline includes MP0274, a multi-DARPin that targets HER2, providing broad blockade of HER1, HER2 and HER3-mediated signaling and inducing apoptosis (programmed cell death) in HER2-overexpressing cells. MP0274 is currently in preclinical development.

Concepts for immuno-oncology pipeline and two early-stage programs announced

In March 2016, the company announced its strategy in immuno-oncology, including the disclosure of two multi-DARPin programs. The first program targets the validated immune checkpoint PD-1 as well as VEGF-A, aiming to enhance PD-1 efficacy. The second program is designed to potently activate T-cells in the tumor only without activating circulating T-cells, thus circumventing systemic toxicities.

Immuno-oncology is a revolutionary approach to anti-cancer treatment that redirects the body’s immune system to fight cancer cells. Investigators are studying many different ways to modulate immune checkpoints used by the body to regulate the immune system. While many of these clinical studies are yielding promising results, novel approaches are needed.

Abicipar advances in phase III trials, reiterated commitment of strategic partner Allergan

Molecular Partners is pleased to see abicipar advancing in its Phase III trials in wet AMD which started in July 2015. The company remains confident to see further development of this product candidate in additional indications such as diabetic macular edema (DME) as well as progress of other DARPins in the ophthalmology alliance with Allergan, which also includes an earlier stage VEGF/PDGF multi-DARPin in wet AMD. In the context of the withdrawn merger of Allergan with Pfizer, Allergan management publicly stated on April 6, 2016, that abicipar “continues to progress in clinical development and could be a true game changer for people suffering with this disease by lowering the injection burden significantly.”

Financial Highlights in 1Q 2016: Financial development as expected, ongoing strong position

In the first quarter of 2016, Molecular Partners recognized total revenues of CHF 6.8 million (1Q 2015: CHF 5.8 million) and incurred total expenses of CHF 9.0 million (1Q 2015: CHF 6.2 million). This led to an operating loss of CHF 2.2 million for the quarter (1Q 2015: operating loss of CHF 0.4 million). The company recognized net financing expenses of CHF 2.0 million (1Q 2015: net financing expenses of CHF 2.0 million), mainly driven by negative FX effects on USD and EUR cash positions. This resulted in a net loss of CHF 4.2 million for the first quarter 2016 (1Q 2015: net loss of CHF 2.4 million).

The net cash used from operating activities during the first quarter 2016 was CHF 7.2 million (1Q 2015: net cash used from operating activities of CHF 3.8 million). Including the time deposits, the cash and cash equivalents position of the company decreased by CHF 9.5 million versus year-end 2015 to CHF 205.9 million as of March 31, 2016 (December 31, 2015: CHF 215.4 million). The total shareholders’ equity position decreased by CHF 4.8 million to CHF 147.0 million as of March 31, 2016 (December 31, 2015: CHF 151.8 million).

As of March 31, 2016, the company employed 94 FTEs, more than 90% of whom are employed in R&D functions (December 31, 2015: 89 FTEs; March 31, 2015: 75 FTEs).

Key figures as of March 31, 2016

Key Financials (unaudited)
(CHF million, except per share, FTE data)

1Q 2016

1Q 2015

change

Total revenues

6.8

5.8

1.0

R&D expenses

-7.5

-4.6

-2.9

G&A expenses

-1.5

-1.6

0.1

Operating loss

-2.2

-0.4

-1.8

Net loss

-4.2

-2.4

-1.8

Basic net loss per share (in CHF)

-0.21

-0.13

-0.08

Net cash from (used in) operating activities

-7.2

-3.8

-3.4

Cash & cash equivalents as of March 31

196.3

182.3

14.0

Cash balance (incl. time deposits) as of March 31

205.9

182.3

23.6

Total shareholders’ equity as of March 31

147.0

146.5

0.5

Number of total FTE as of March 31

93.7

74.8

18.9

– thereof in R&D

85.5

67.9

17.6

– thereof in G&A

8.2

6.9

1.3

“In the first quarter of 2016, Molecular Partners’ financial position developed fully in line with our projections and expectations amid the substantial scale-up of our R&D and operational activities,” said Andreas Emmenegger, Chief Financial Officer of Molecular Partners. “We reiterate our previously provided financial guidance for 2016.”

Successful placement of shares

After the end of the first quarter, on April 13, 2016, employees, consultants, members of the board of directors of the company as well as certain venture capital shareholders successfully placed 1.1 million shares in an accelerated bookbuilding transaction at a price of CHF 27.50 per share. This share placement was done in order to provide employees, consultants and members of the board of directors the necessary funds to pay taxes and social securities resulting from the exercise of stock options which were approaching expiration. Following the option exercise and transaction, the executive management team holds an increased position of Molecular Partners’ shares compared to the situation before the share placement.

Business outlook and priorities

With the announcement of the share placement transaction on April 13, 2016, Molecular Partners AG fully confirmed its outlook and priorities for the financial year 2016.

In ophthalmology, the company will remain focused on supporting its partner Allergan in progressing abicipar through Phase III trials in wet AMD, and possibly in initiating Phase III trials for abicipar in DME.

In oncology, Molecular Partners AG reiterated during the first quarter 2016 its commitment to conduct a Phase II trial of MP0250 in the treatment of multiple myeloma (MM) in combination with bortezomib and dexamethasone, and continues to expect the enrolment of the first patient in the second half of 2016. The company’s management team also remains committed to advancing MP0274 into clinical development in 2016, and plans to initiate a Phase I trial of MP0274 by the end of the year.

On March 7, 2016, Molecular Partners AG reinforced its key priority on contributing to the rapidly evolving field of immuno-oncology as the DARPin platform is ideally suited to develop differentiated immuno-oncology therapies with the potential to overcome some of the limitations of first-generation approaches. The company announced initial strategies of its proprietary immuno-oncology pipeline, including two multi-DARPin programs which are evaluating new principles that were previously difficult to achieve.

Financial Outlook 2016

Molecular Partners reiterates all elements of the financial outlook 2016 as provided in the company’s 2015 full-year results on February 4, 2016.

For the full year 2016, at constant exchange rates, the company expects total expenses of CHF 50-60 million, of which around CHF 6 million will be non-cash effective costs for share-based payments, IFRS pension accounting and depreciations. However, this may change substantially depending on the progress of the pipeline, mainly driven by the speed of enrollment of patients in clinical trials and data from research and development projects. Additionally, the company expects around CHF 3 million of capital expenditures, mainly for laboratory equipment.

No guidance can be provided with regard to net cash flow projections. Timelines and potential milestone payments for existing and potentially new partnerships cannot be disclosed.

Financial Calendar 2016

Publication of Half-year Results 2016

September 1, 2016

Publication of Quarterly Management Statement Q3 2016

October 27, 2016

http://investors.molecularpartners.com/financial-calendar-and-events/

 

About Molecular Partners AG

Molecular Partners AG is a clinical-stage biopharmaceutical company that is developing a new, class of therapies known as DARPins. DARPins are potent, specific, and versatile small-protein therapies, which have the potential to offer benefits over conventional monoclonal antibodies or other currently available protein therapeutics. The DARPin technology has the potential to offer a multi-specific approach to treatment, which enables DARPins to target multiple pathways, or multiple epitopes on a single target to achieve substantial patient benefit. DARPins have the potential to advance modern medicine and significantly improve the treatment of serious diseases, including cancer and sight-threatening disorders.

Molecular Partners has four compounds in various stages of clinical and preclinical development and several more in the research stage, with a current focus on ophthalmology and oncology. The company has ongoing research and development partnerships with leading pharmaceutical companies, including Allergan and Janssen, and is backed by established biotech investors. For more information regarding Molecular Partners AG, go to: www.molecularpartners.com.

For further details, please contact:

Dr. Christian Zahnd, CEO
christian.zahnd@molecularpartners.com
Tel: +41 (0) 44 755 77 00

Andreas Emmenegger, CFO
andreas.emmenegger@molecularpartners.com
Tel: +41 (0) 44 755 77 00

Rolf Schläpfer
Hirzel.Neef.Schmid.Counselors
rolf.schlaepfer@konsulenten.ch
Tel: +41 (0) 43 344 42 42

 

Disclaimer

This communication does not constitute an offer or invitation to subscribe for or purchase any securities of Molecular Partners AG. This publication may contain certain forward-looking statements and assessments or intentions concerning the company and its business. Such statements involve certain risks, uncertainties and other factors which could cause the actual results, financial condition, performance or achievements of the company to be materially different from those expressed or implied by such statements. Readers should therefore not place reliance on these statements, particularly not in connection with any contract or investment decision. The company disclaims any obligation to update these forward-looking statements, assessments or intentions.